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Yonghong Liang Ph.D. Moʻomōʻali

Yonghong Liang Ph.D. Moʻomōʻali

ʻO ka hana nui

Ke KānāwaiʻIke

  • Sep. 2006-i kēia manawa Hana i ka Ph.D (Organic Chemistry)
    hana
    1. ʻO ke aʻo kūpono o ka pilina ma waena o kapivirine (TMC120) a me ka HIV-1 hoʻohuli transcriptase
    2. ʻO nāʻano hana piliʻoihanaʻoihana o ka benzyl pani i diarylpyrimidines
    3. Ke kaulike, ka hoʻomanaʻo a me nā haʻawina SAR o nā diarylpyrimidines a α a me β i ka liʻa a me ka β i lilo i ka mea non-nucleoside o ka HIV-1 hoʻohuli transcriptase
    4. Hoʻonohonoho a me ka hoʻomanaʻo o DABO i mau mea hōʻailona lua o ka HIV-1 hoʻohuli transcriptase a hoʻokomo

  • 2003-2006 Kumu Hoʻoponopono
    hana
    1. ʻO ka'āina- a me ka neʻeʻana o ka'ōmole intramolecular prox for 2-hydroxybenzophenone, 8-hydroxy-4H-naphthalen-1-one, 5-hydroxy-4, 5-naphthoquinone, 1-hydroxy-9, 10-anthraquione, 7-Hydroxy -1-indenone, 5, 8-dihydroxy-1, 4-naphthoquinone), 4, 9-dihydroxyperylene-3, 10-quinone a me ka hypocrellin A ua aʻoʻia ma nāʻano papa.
    2. ʻO ka hoʻohālikelike o ka'āina-inermolecular proton i nā hale o ka 5-hydroxyisoxazole-wai, ke kumu hoʻohālike DNA (RNA) a me ka waihona-N-methylformamide i hanaʻia e nā mode DFT.
    2002-2003ʻO keʻano o ka pilina o ka hoʻohui waiwai ma ka physicochemical property of ketone and aldehyde

Awards

ʻO ke kula kiʻekiʻeʻo Hunanʻo Master Thesis, 2008

Publications

1. Liang, YH; Kino, FE ONIOM DFT / PM3 helu i ka pilina o waenandapivirine a me ka HIV-1 hoʻohuli transcriptase, kahi aʻo kūpono. Drug Discov. ʻOi. 2007, 1, 57-60.

2. Liang, YH; ʻO Chen, FE QSAR no nā diarylpyrimidines e kū'ē i ka maʻi HIV-1 a me nāʻano mutual transcriptase. Eur. J. Med. ʻO Chem. 2009, 44, 625-631

3. Liang, YH; Feng, XQ; Zeng, ZS; Kan, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Design, Synthesis, and SAR of Naphthyl-Substituted Diarylpyrimidines like Non-Nucleoside Inhibitors of HIV-1 Transverse Course. XMUMUM 2009, 4, 1537-1545.

4. Feng, XQ; Liang, YH; Zeng, ZS; Kan, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Nānā Kūkulu o DAPY mau Analogues me ka Hana Kūikawā Anti-HIV-1. XMUMUM 2009, 4, 219.

5. Zeng, ZS; Liang, YH; Feng, XQ; Kan, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Ke kohoʻana i nā diarylpyrimidines e like me nā mea hoʻopunipuni o ka non-nucleoside HIV-1 hoʻohuli transcriptase, ChemMedChem 2010, iʻaeʻia.

6. Liang, YH; Hana, PG He kūmoleʻike i keʻano, ka ikaika, a me ka intramolecular proton transition of alkʻan. Nā Lettters Pono Maʻemaʻe, 2007, 438, 173.

7. Liang, YH; Hana, PG; Peng, HL Nā haʻawina kūikawā o ka hana, ikaika a me ka intramolecular hydrogen transfer of hypocrousllin A. Nā mea leka uila, 2008, 466, 6-10.

8. Liang, YH; Hana, PG. Cao, CZ A no keʻano o ka loiloiʻana no ka hoʻokuʻuʻana i ka proton i 5-hydroxyisoxazole. Ka Moʻolelo o ka Molecular Structure: Theochem, 2005, 729, 163-167.

9. Hana, PG .; Liang, YH; Cao, CZ Intramolecular Proton aiʻole ka hoʻohāwai hydrogen-atom ma ka honua a me nāʻano hauʻoli o 2-hydroxybenzophenone: Keʻanoʻoihana. Niko Lapaʻau, 2005, 319, 297.

10. Hana, PG .; Liang, YH Nāʻike no ka piliʻana i ka hopena a me nā hopena o ka hopena o ka proton kahe i ka honua a me ka'āina. Niko Lapaʻau, 2006, 322, 382.

11. Hana, PG .; Liang, YH Tang, ZQ Hoʻomaopopo kūpono o ka neʻeʻana o ka protoncular proton i ke keleponaʻo 5-hydroxyisoxazole-wai. Niko Pono, 2006, 2006, 322, 387.

12. Liang, YH; Zeng, ZS; Feng, XQ; Kan, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Parallel Hoʻohālikelike a me ka Hoʻohālike Ola Olaʻana o Diarylpyrimidines me ka Hana Kūikawā Anti-HIV-1. ʻO Med. ʻO Chem. 2010, 18 (13), 4601.

13. Liang, YH; Zeng, ZS; Feng, XQ; Kan, FE; Balzarini, J .; Pannecouque, C .; De Clercq, E. Hoʻolālā o nā DABO e like me nā mea hōʻailonaʻelua o ka HIV-1 hoʻohuli transcriptase a hoʻokomo. J. Med. ʻO Chem.

14. Chen, FE, Liang, YH no ka holomua o nā Haumāna KūikawāʻoʻAi-ʻAmelika, Niko i ke Kauka'Emelika (8), Peng, SQ Ed., 2011, 167.

15. Chen, FE, Liang, YH, Zeng, ZS PCT / CN2009 / 075931.

16. Zeng, ZS, Liang, YH, Zhang, JY, Xiong, JC China Patent, CN201110070027.4

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