4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9)

(2 Customer hōʻike manaʻo)

Ke noho nei kēia huahana ma kahi palapala pāʻani APICMO.

Ka hiki ke hana, synthesi a hana i nā mea nui o ka 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9) me ka pūnaewele maikaʻi ma lalo o ka CGMPʻoihana
nā kauā.

Māhele:

Description

4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9) video

He poʻokelaʻo Janus kinases (JAKs) i ka unuhiʻana o ka transit translation transmitter cytokine. Ua puka mai nā mea kū'ē iā JAK ma keʻano he mau mea hana kūkahu kūponoʻole no ka paleʻana i ka hōʻoleʻiaʻana o ka halihaliʻana. Ua hōʻike mua mākou ma mua o ka meaʻo 2 tricyclic imidazo-pyrrolopyridinone he mea hoʻouka kauaʻo JAK; akā, ua loaʻa kaʻona ohe waha ma muli o ka liʻiliʻi o ka membrane. Maanei, hōʻike mākou i ka hoʻololi hoʻolālā o 2 i loko o ka tricyclic dipyrrolopyridine 18a e hoʻonāukiuki ana i ka ho'ēmi o kahi'āpana pola (PSA), e hōʻike ana i ka hanana i loko o ka vitro, maikaʻi maikaʻi o ka membrane a me ka bioavailability maikaʻi. Hōʻike ka 18a i ka mana i ka'ōlohelohe transplants heterotopic.

Ke noho nei kēia huahana ma kahi palapala pāʻani APICMO. Ināʻikeʻoe i kēiaʻaoʻao ma keʻano he mea hoʻohanaʻoleʻia,ʻo ke kumukūʻai i hōʻikeʻia he List Price. No kaʻikeʻana i kāu kumukūʻai, e hoʻopaʻa i ka hoʻohanaʻana i kāu helu helu, aiʻole e liloʻoe i mea hoʻohana inoaʻia e ke kākoʻoʻana i kahi o kā mākou hui lawelawe. No ka hoʻonohonohoʻana i kahi kauoha, e hoʻopili i kahi lawelawe o ka APICMO.

4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9) Specifications

CAS 918515-16-9
Ke kaʻina CAS% 95%
Kālena CAS Max% 100%
MDL Number ʻO MFCD09880129
InChI Key DYWWVLQMUUZZRJ-UHFFFAOYSA-N
Ka inoa inoa inoa 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde
Pāʻani infrared pono
ʻO ke Kino ʻO ka'ōmaʻomaʻo keʻokeʻo
'ōpala ʻO ka'ōmole Glass
Ka Lā Molecular C8H5N2OCl
Molecular Weight (g / mol) 180.594
SMILES ClC1 (= C2 (C (= NC = C1) NC = C2C =ʻO))
kala like 'ole Keʻokeʻo
ʻO Boiling Point 372.6 ° C ma 760 mmHg
ʻAna 98%

4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9) Ke kaukana a me ka lima

  • Mai hoʻomaha i ka lepo a me kaʻahu.
  • E mālama i kaʻauʻau a me ka holoi maka.
  • Mai komo i ka maka, i kaʻili a i kaʻaʻahu.
  • E hoʻopaʻa paʻa i ka pahu.
  • E kūʻai i kahi hoʻomaha, maloʻo, kahi maikaʻi.
  • E hōʻoia i ka palekana maikaʻi i ka hoʻohanaʻana.
  • E hoʻohana wale i ka hale hana hoʻolālā.

'Ōlelo Aʻo: Ua hoʻokumuʻia kaʻike i hoʻolakoʻia ma kēia pūnaewele e like me nā kānāwai o ka Europa (EU) a ua kūpono i ka maikaʻi o ko mākouʻike, kaʻike a me ka manaʻo i ka lā o kona hoʻolahaʻana. ʻO kaʻike i hāʻawiʻia i kūkuluʻia wale nōʻo ia ke alakaʻi no ka mālama pono a hoʻohanaʻana. ʻAʻole pono e noʻonoʻoʻia e like me ke kikowaena a iʻole ke kiko kiko'ī.

4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9) Articles

Ka weheweheʻana o nā hua'ōlelo tricyclic dipyrrolopyridine ma keʻano he papa hoʻopuka a JAK

He poʻokelaʻo Janus kinases (JAKs) i ka unuhiʻana o ka transit translation transmitter cytokine. Ua puka mai nā mea kū'ē iā JAK ma keʻano he mau mea hana kūkahu kūponoʻole no ka paleʻana i ka hōʻoleʻiaʻana o ka halihaliʻana.

ʻO Biomino a me Medicinal Chemistry 2017

Ke kuhi a me ka hoʻolālā olaʻana o nā pyrrolo [2,3-b] pyridine analogues e like me nā mea hana antiproliferative a me kā lākou mau pilinaʻana me kaʻulaʻula hermus DNA

ʻO ka lālani he kanakolu kumamālua o nāʻano pyrrolo [2,3-b] pyridine ana i synthesized, e hōʻikeʻia ana (1H NMR, 13C NMR a MS) a me ka loiloi cytotoxic o kēia mau molekila i hanaʻia ma luna o kahi papaʻaina o nā līlū pūkuniapoʻekolu e like me A549

ʻO ka European Journal of Medicinal Chemistry 2016

Nānā Hanahana:

Loaʻa kaʻike o kā mākou pūʻuluʻepekema ma nā wahi noiʻi a pau e pili ana i Life Science, Material Science, Synthesis Chemical, Chromatography, Analytical a me nā mea'ē aʻe.

4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9) Kūlana Hoʻohanohano & Pricing:

Loaʻa i nā mea nui no kāu kūkuluʻana, hana hana a noiʻi noiʻi paha?


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2 hōʻike manaʻo no ka mea, 4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9)

  1. APICMO -

    Ma APICMO, hoʻolaha a hana mākou i ka nui o ka 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde, me nā mea'ē aʻe. ʻO kā mākou mau huahana e mālama i nā papahana hanahana CGMP a he nui no ka noiʻi, hoʻolālā, a me ka hanaʻana.

    4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde Hōʻike

    ʻAʻole pilikiaʻo JAKs a Janus paha i ka unuhiʻana o ka hōʻailona o ka cytokine. Ua hoʻokūpaʻa ka noiʻi i nā mea hoʻonāukiuki o JAK e lilo i mau mea palekana, e pale pono i nā hoʻololi o ke koho. I ka manawa mua, tricyclic imidazo-pyrrolopyridine2 ko mākou keʻakeʻa nui JAK a hiki i ko mākouʻikeʻana iā ia he kūpona liʻiliʻi liʻiliʻi e hoʻonā i ka hoʻonaniʻana.

    ʻO ka hoʻololiʻana i ka hoʻololiʻana i ka māmā tricyclic imidazo-pyrrolopyridine 2 e ho'ēmi ana i ka'āpana pola, no laila, e hoʻonui i ke tricyclic imidazo-dipyrrolopyridine. ʻO kēia pūpū uaʻoi aku ka maikaʻi o ka pīhoihoi me ka hoʻonani kūpono maikaʻi, a me ka'ikexhibits i nā hana vitro ikaika. I ka manawa i lawelaweʻia ai i loko o keʻano o ka halihali kāpili āpau a ka iole, ua maikaʻi loa.

    (918515-16-9) Hōʻike Huahana

    'O Synonyms · 4-Chloro-7-azaindole-3-carbaldehyde

    · 4-Chloro-3-formyl-7-azaindole

    ʻO ke kumuhana hana 4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde(918515-16-9)
    Purity 98% maikaʻi
    ʻO ke kino paa
    Ka monoisotopic mass (g / mol) 180.009
    ʻO ke kaumaha kaulike (g / mol) 180.591
    ʻO ke kumu hāmeʻe C8H5ClN2O
    Pākuhi Flash (˚C) 179.1
    'Aiha (g / cm3) 1.521
    Inoa inoa inoa 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde
    ʻAʻole CAS no. 918515-16-9
    Kaʻaila hoʻouluʻia (˚C) 372.6 ma 760 mmHg

    4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde

    Nā Māliko a me nā Pono o

    ʻO ke kūlana

    4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde ke kiʻekiʻe loa ma nāʻano maʻamau. Eia naʻe, ka hopena o kaʻike o ka huahana i nā mahana kiʻekiʻe, hoʻomehana, aiʻole nā ​​mea hana ikaika hoʻonalowale e like me ka mea e hoʻomaka ai ka hopena.

    4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde Hoʻohui

    Kahi paʻa wai Helu helu Donor - 1 pūnaewele

    Helu helu hōʻailona - 2 pū

    Kohu
    Ka loulou paʻa 1

    Keʻano

    4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde he mea paʻa keʻokeʻo.

    4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9): Computed Properties

    Kahi inoa ʻO ke kumu waiwai
    Ka nui 188
    Hoʻokomoʻia ka papahana ʻAe
    Hoʻomākaukau'Āina Atom 0
    Ka Heluhelu Hoʻohālike Bond Bond 0
    ʻO ka komoʻana o ka vaporization (kJ / mol) 61.97
    ʻIke kūpono (g / mol) 180.009
    Kāleka Kūikawā 0
    Heluhelu Atomona Heavy 12
    Hoʻomākaukauʻo Isotope Atom 0
    Mokuna Polar (PSA) 45.75ʻA2
    Hōʻike kuhikuhi 1.748
    Ke kele 'āpana (dyne / cm) 71.9
    Wahi puni pola 45.8 A '2
    ʻO ka heluʻo Atom Stereocenter 0
    Ka helu helu hōʻemiʻole 0
    Kaohi kaohi (mmHg) 9.53E-6
    XLogP3-AA 1.4

    Ke alanui Kūʻai o 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde

    Ma lalo iho neiʻelua mauʻano o ka synthesizing i ka huahana:

    ʻO Tetrahydro-4-pyranol (2081-44-9)

    4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9): Uses

    ʻO ka huahana he mea lāʻau lapaʻau waena, e lawelawe ana i ka mea hoʻokipa JAK no ka paleʻana i ka hoʻohuliʻiaʻana o ke kolo

    Nā pōʻino i pili pū me 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde

    • ʻO kaʻino i ka wā i komo ai a hoʻomele ai i ka huhū o ka hanu, ka liʻiliʻi o ka hanu, aiʻole ka nausea
    • Hana i ka corrosion, kaʻulaʻula, aiʻole kaʻeha o kaʻili i ka manawa e kū pololei ai
    • Paʻawa i ka wā i aleʻia ai, e alakaʻi ana i ka pōʻino
    • Ka hanaʻino a iʻole ka hoʻomau mau loa

    Nā palekana no ka lawelaweʻana me 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde

    1. Ke Kuleana pilikino

    Lawe i kahi pale nui me ka hoʻolālā e hoʻomaʻemaʻeʻia ai ka makani e pale ai i nā ulia pōpilikia, iʻole e hoʻonāukiuki i ka tract respiratory. No kou mau lima a me kou mau wāwae, e kau i nā mīkina pale lima a me nā kāmaʻa ukiuki, kēlā me kēia. Lawe i kahi halihali holoʻokoʻa e uhi a pale i kaʻili.

    2. (918515-16-9): Mana Pūnaewele

    E hōʻoia i kāu wahi hana i kahi kīʻaha fume, nā pā, nā mea e hoʻomaʻemaʻe ai i nā ea, ka pale pale, nā maka maka, a me nā hale lole hiki ke nānā aku.

    3. ʻO nā mea kōkua mua

    • Inhalation

    E holoi i ka waha no nā mau minuke 10. E inu i ka wai nui e like me ka hapalua lila. Inā hōʻoia ka hoʻomau pinepine, e hoʻohuli i kahi kikowaena iʻole e huli i kaʻike.

    • Ka hulina pilikino

    Wehe koke i nā lole i haumia. E holoi i kahi'āpana me kahi wai e holo ai no nā hola 15. E huli i ka manaʻo o kahi lāʻau lapaʻau ke kū ka maʻi.

    • Inhalation

    E hoʻoneʻe i ka mea i kahi maʻi i kahi lumi me ka hoʻolālā nui a waho paha. Inā paʻakikī nā hōʻailona e like me ka hoʻonāukiuki, hoʻopuka i ka hāpai o oxygen a nīnau i ke kauka.

    • Nānā maka

    Wehe i nā leka hulina inā loaʻa iā lākou. E hoʻopili i nā maka i ka nui o ka wai no nā minuke 10 e hiki mai nei.

    4. Ke hoʻohanaʻana iā 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde

    Ke hoʻohanaʻia ka huahana, e noʻonoʻo i nā helu ma lalo:

    • E hoʻohana iā ia i loko o ka hale kī
    • Lawe mākou i nā pale pale e like me nā kūlana palekana hana o ka moku a me ka moku'āina
    • E hana i loko o kahi lumi me ka puʻupuʻu nui

    5. Ma hope o ka hoʻohana

    Ma hope o ka hoʻohanaʻana i ka 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde, eia kekahi mau mea e lawe ai:

    • E kūʻai i ke koena i lalo o nā mahana haʻahaʻa
    • E hoʻokuʻu i nā pahu me nā koena i kūpono
    • E holoi i nā lima
    • Wehe i nā lole i holoiʻia a holoi iā lākou ma mua o ka hoʻohana houʻana

    6. Ke hele ma waho o ka hoʻohanaʻana

    Ke hoʻohanaʻoleʻia,

    • Hoʻopili i ke kinowai i kahi sila paʻa e palena ai i ke komoʻana
    • E hoʻomau i ka lama
    • E hōʻole i ka hōʻikeʻana i ka wela aiʻole nā ​​mea hana'ē aʻe

    7. 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-Carbaldehyde Pūnaewele a me ka lawelawe limaʻana

    pūnaewele

    • E mālama iā ia i ka uila,ʻoi aku ma -20˚C
    • E kūʻai i loko o nā pahu pahu paʻa
    • E waiho ma kahi maloo a maloʻo
    • Hoʻopili i ke kinipona i nā pahu i hoʻopaʻaʻia e pale i ke komoʻole

    e lawelawe ana

    • Lawe i nā mea pono pilikino
    • E hoʻohana i kahi hale hoʻumehana lāʻau
    • E hana ma kahi ākea a kahi lumi hoʻomaha maikaʻi
    • Mai hoʻoluliluli i nā'ōmole, ka kino, ka lepo, a me nā mea'ē aʻe

    8. Ke ahi

    Lawe i nā lole pale a me nā mea hoʻomaha. E hoʻopau i ka lapalapa ahi, ka carbon dioxide, aiʻole kahi maloʻo maloʻo maloʻo. ʻO nā hopena kūmole o 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde e komo pū nā mea kau o ka hauū, HCl, a me carbon monoxide.

    9. Hoʻoponopono i nā Hoʻolaha

    Ke hoʻokaeʻia ka wai, e hoʻokuʻu me kahi mea humuhumu i loko, e hoʻomaʻemaʻe, ae waiho i loko o ka pahu inoa a me ka pani. No kahi kūpaʻa paʻa, hoʻopiʻi i ka meaʻonika a hoʻopauʻia ia. Maiʻae i nā paepae eʻike i ko lākou ala i nā kahawai wai aiʻole nā ​​luawai.

    10. Ka palekana paʻa a me ka hana hou

    11. Paʻa Waiwai

    Nānā i ka 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde e like me ka hoʻokuʻu kūikawā a hāʻawi aku e like me nā rula o nā hoʻokuʻu hoʻokuʻu'āina / state / federal. Ke hoʻohanaʻia nā lawelawe a kahi hui kaiaulu, e hōʻoia ua hoʻopaʻa inoaʻia a ua laikiniʻia.

    12. 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9): ka moku kūʻai.

    ʻAʻohe meaʻikeʻoleʻia me ka ea a me ka lawe honua o ka 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde.

    Hoʻoponopono Kōnae

    ʻO ka mea hōʻailona a me ka paepae pae o 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde e mālama ana i ka palena kūpono i hōʻikeʻia e nā SARA Title III mau paukū 302 a me 313.

    4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde: Keʻano o nāʻike

    Loaʻa ka pōkole nui o kā mākou mau noiʻi noiʻi noiʻi i nā haʻawina waiwai a me nāʻike waiwai, nā kānanaʻenehana, nā mele, a me ka chromatography.

    4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9): Ka hoʻonohonohoʻana a me ke ukuʻana.

    Inā makemakeʻoe iā 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde ma kahi nui, no kāu noiʻi a me kāu uluʻana, e kau i kāu kauoha me mākou ma ke kākoʻoʻana i kā mākouʻoihana lawelawe.

    ʻia ....................

    1. Ke KōmikeʻOihana No ka'Ipele'Eolahana, US. Ka Waihona Puke o ka Hale Waihona Puke, Pubchem4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde, Mahele 1-10
    2. Nāoki Katsuki, Shumpei Isshiki, Juan Okamura, Kouji Kuramochi,, a me Kazunori Tsubaki ʻO ka Journal of Organic Chemistry2017 82 (21), 11563-11572
    3. Ihle JN, Thierfelder W, Teglund S, et al. Hōʻailonaʻia e ke kāpenaʻokoʻa cytokine superfamily. Ann NY Acad Sci. 1998; 865: 1-9

  2. Apicmo -

    ʻO 4-Chloro-1h-pyrrolo mea nui loa [2,3-b] pyridine-3-carbaldehyde a me ka lawelawe i loaʻa iaʻu, kaʻike maikaʻi.

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