2,8-Diazaspiro[4.5]decan-3-one (561314-57-6)

(2 Customer hōʻike manaʻo)

Ke noho nei kēia huahana ma kahi palapala pāʻani APICMO.

Ka hiki ke hana, synthesi a hana i nā mea nui o ka 2,8-Diazaspiro [4.5] decan-3-one (561314-57-6) me ka pūnaewele maikaʻi ma lalo o ka ulana CGMP.
nā kauā.

SKU: 561314-57-6 Māhele:

Description

2,8-Diazaspiro[4.5]decan-3-one (561314-57-6) video

I loko o ka ho'āʻoʻana e hoʻomohala i nā mea kū'ē pono GPIIb-IIIa me ka hoʻonuiʻana i nā mea kūʻai lāʻau, ua hoʻohana mākou i kahi hanana 2,8-diazaspiro [4.5] decane scaffold ma keʻano he kikowaena. Ke ho'ākāka nei maʻaneʻi i ka hoʻokolokoloʻana i nāʻano likeʻole me nā spiropiperidinyl-γ -lactams, spiropiperidinylimide, spiropiperidinylureas, a me spiropiperidinylhydantoins. Me nā waikiko waikawa a me nā kānipona maʻamau i kū i kahi, ua hāʻawiʻia kēlā me kēia template analogues me ka hana hana hoʻopunipuni GPIIb-IIIa. Hoʻohanaʻia kekahi o nā pūnaewele,ʻo 59 (CT50787), e hōʻike i ka manawa mua i ka hoʻohanaʻana o kahi luna pharmacologicalʻo iaʻo αIIbβ3 kūikawā e hōʻike i ka hana olaola i loko o nā mea haʻahaʻa e like me kaʻiole a hoʻonui i ka manawa o ke koko. ʻO ka loiloiʻana i nā huahana pharmacokinetic o nā wae i waeʻia mai kēlā me kēia hui o ka'īlio, ka'īlio, a me ka monkey cynomolgus ua alakaʻiʻia i ka hōʻoiaʻana o 22 (CT51464), heʻelua mau huahana, me nā mea pharmacokinetic maikaʻi loa. Hōʻikeʻia i kaʻike o ka lāʻau pharmacokinetic maikaʻi e pili ana i nā mea likeʻole (Fpercent = 33 (Cyno), 73 ('īlio), 22 (rat); t1 / 2β = 14. 2 h (Cyno), 8.97 h (dog), 1.81 h (rat)). ʻO ka'ōnaehana biologically active, 23 (CT50728), hōʻikeʻia ka pāpālua o ka hōʻiliʻiliʻia o ka platelet i loko o ka plamma waiwai nui (PRP) me ka nui o ka IC50 o 53 nM ma kahi pahu paona, 110 nM i PPACK e pili ana i PRP, a me 4 nM i loko o kahi paʻa GPIIb-IIIa. ka hoʻokūkū hoʻokūkū (ELISA). Hoʻokumuʻia ka 23 a me ka 22 i nā microsomes o nāʻano o ke kanaka,ʻaʻole i kāohi i ka P450 3A4 isozyme, a me ka paʻaʻana o ke kalapona (18.22percent for 23) a me kahi P (0.45 ± 0.06 i makemakeʻia no 22, a me -0.91 ± 0.32 no 23). Ua wānanaʻiaʻo ka loli kūpono o nā kola nui no kēia mau pūnaewele i loko o nāʻano he nui e unuhi i lalo i ka hoʻololi i loko a me ka intersubject i loko o ke kanaka. ʻO ka hapalua o ka plasma lōʻihi o ke alakaʻi e like me ka hoʻokahi aʻelua manawa o ka hoʻomalu no ka hoʻomaha maʻi. Hanaʻia ka 22 (CT51464) analogue i mea hoʻolālā o GPIIb-IIIa wahaʻo e hāpai ana i nā meaʻoihana pharmacokinetic maikaʻi loa ma luna o nā mea i hoʻomoakakaʻia i mua i ho'ākāka muaʻia a he mea pono paha i ka mālamaʻana i nā maʻi o nā kino.

Ke noho nei kēia huahana ma kahi palapala pāʻani APICMO. Ināʻikeʻoe i kēiaʻaoʻao ma keʻano he mea hoʻohanaʻoleʻia,ʻo ke kumukūʻai i hōʻikeʻia he List Price. No kaʻikeʻana i kāu kumukūʻai, e hoʻopaʻa i ka hoʻohanaʻana i kāu helu helu, aiʻole e liloʻoe i mea hoʻohana inoaʻia e ke kākoʻoʻana i kahi o kā mākou hui lawelawe. No ka hoʻonohonohoʻana i kahi kauoha, e hoʻopili i kahi lawelawe o ka APICMO.

2,8-Diazaspiro[4.5]decan-3-one (561314-57-6) Specifications

CAS 561314-57-6
Ke kaʻina CAS% 95.0
Kālena CAS Max% 98.0
MDL Number ʻO MFCD11044206
InChI Key ASPBBYVNTIMKLA-UHFFFAOYSA-N
Ka inoa inoa inoa 2,8-Diazaspiro [4.5] decan-3-hoʻokahi
Pāʻani infrared pono
ʻO ke Kino N / A
'ōpala ʻO ka'ōmole Glass
Ka Lā Molecular C8H14N2O
Molecular Weight (g / mol) 154.212
SMILES C1CNCCC12CC (=ʻO) NC2
kala like 'ole melemele
Point Hoʻolālā N / A
ʻAna ≧ 98%

2,8-Diazaspiro [4.5] decan-3-one (561314-57-6) Ke kūlana palekana me ka lawelawe limaʻO nā'āpana'ōpala APICMO

2,8-Diazaspiro [4.5] decan-3-hoʻokahi Palapalaʻanoʻino:

w Inā hōʻinoʻia

w He kaumaha nui ka maka.

w Hoʻopilikia i kaʻili.

w E hana i ka huhū o ka hanu.

w E hōʻoki i ka lepo / fume / gas / mist / vapors / pālolo.

561314-57-6'ōlelo kūkala:

w E hōʻoki i ka lepo / fume / gas / mist / vapors / pālolo.

w Wear pale pale a me ka pale maka / maka.

I KA IE EESE: E kiola me ka wai no nā minuke. Wehe i nā leka hulina, inā he mau a hiki ke maʻalahi. E hoʻomau i ka holoi.

'Ōlelo Aʻo: Ua hoʻokumuʻia kaʻike i hoʻolakoʻia ma kēia pūnaewele e like me nā kānāwai o ka Europa (EU) a ua kūpono i ka maikaʻi o ko mākouʻike, kaʻike a me ka manaʻo i ka lā o kona hoʻolahaʻana. ʻO kaʻike i hāʻawiʻia i kūkuluʻia wale nōʻo ia ke alakaʻi no ka mālama pono a hoʻohanaʻana. ʻAʻole pono e noʻonoʻoʻia e like me ke kikowaena a iʻole ke kiko kiko'ī.

Articles

Ka Discovery o ka Nūpepa 2,8-Diazaspiro [4.5] decanes e like me Glycoprotein IIe-IIIa KūloheloheMehrotra,

Ma kā mākou mau hana e hoʻolālā i nā mea'onike GPIIb-IIIa me nāʻoihana olakino maikaʻi, ua hoʻohana mākou i kahi palapala 2,8-diazaspiro [4.5] decane scaffold ma keʻano he kikowaena ... Journal of Medicinal Chemistry 2004.

2,8-Diazaspiro [4.5] decan-3-hoʻokahi (561314-57-6) Keʻena Hana Hana Hana:

Loaʻa kaʻike o kā mākou pūʻuluʻepekema ma nā wahi noiʻi a pau e pili ana i Life Science, Material Science, Synthesis Chemical, Chromatography, Analytical a me nā mea'ē aʻe.

2,8-Diazaspiro [4.5] decan-3-one (561314-57-6) Pūnaehana Hoʻohanohano & Pricing:

Loaʻa i nā mea nui no kāu kūkuluʻana, hana hana a noiʻi noiʻi paha?


=

2 hōʻike manaʻo no ka mea, 2,8-Diazaspiro[4.5]decan-3-one (561314-57-6)

  1. APICMO -

    APICMO, hoʻolaha mākou, hana a hana i ka 561314-57-6 ma ka pahu nui a ma ka koleko loa a me nā kūlana kūpono. Hoʻopili nā hualoaʻa a pau i nā rula i kauʻia e CGMP ma ka mana maikaʻi i ka hanaʻana.

    561314-57-6 Hōʻike

    • 2,8-Diazaspiro [4.5] decan-3-hoʻokahi kaʻano like.
    • ʻO nā'āpana.
    • Kūpū.
    • ʻO nā azetidines.
    • Nā'Amine.
    • ʻO ka Thietanes.
    • ʻO Pyrrolidines.
    • ʻO Bicyclo [1.1.1] pentanes.
    • ʻO Bicyclo [xyz] alkanes.
    • FluoroBlocks.
    • Cubane.
    • Nā Pūkākūkā.
    • Oxetanes.
    • ʻO Cyclobutanes.
    • Cyclopropanes

    2,8-Diazaspiro [4.5] decan-3-hoʻokahi iʻikeʻia he;

    • 3,8-Diazaspiro [4.5] decan-2-hoʻokahi.
    • MolPort-008-154-349.
    • 2,8-diazaspiro [4.5] decane-3-hoʻokahi.
    • 561314-57-6 2,8-Diazaspiro [4.5]decan-3-one.

    ʻO ka inoa IUPACʻo 2,8-diazaspiro [4.5] decan-3-one.

    ʻO Chemical Name o ka huahanaʻo 2,8-diaza-spiro [4.5] decan-3-one.

    2,8-Diazaspiro [4.5] decan-3-hoʻokahi Kūlana Kūlana.

    561314-57-6 CAS

    2,8-Diazaspiro[4.5]decan-3-one (561314-57-6)

    2,8-Diazaspiro [4.5] decan-3-one, 561314-57-6 Hōʻuluʻulu Huahana

    ʻO CAS NO 561314-57-6
    Ka Lā Molecular C8H14N2O
    Molecular Weight (g / mol) 154.213
    'Aiha (g / cm3) 1.129
    Point Hoʻolālā
    ʻO Boiling Point 360.137 ke kiʻekiʻe Celsius ma 760mmHg
    Hōʻike Kūmole 1.533
    Purity 98%
    Monoisotopic Mass (g / mol) 154.111

    561314-57-6 Nā Kino a me nā Pono

    2,8-Diazaspiro [4.5] decan-3-kahi iʻikeʻia e like me ka pauka keʻokeʻo.

    Hoʻohui

    ʻO Covalent Bond 1
    Waiwai Huawai Donor- 2

    Acceptor- 2

    Pāleka hiki ke hoʻololiʻia 0

    ʻO ke kūlana

    • 561314-57-6 kūpaʻa mau i ka mālamaʻiaʻana ma lalo o nāʻano i'ōleloʻia.
    • E hōʻalo i kaʻikeʻana i nā kapuahi ahi, ka lapalapa a me ka wela.
    • Mai hōʻike i nā mea i kāwiliʻoleʻia e like me Acid chlorides, Acid anhydrides, acids a me nā mea hana hoʻoheheʻe.

    2,8-Diazaspiro [4.5] decan-3-one, 561314-57-6 Hana Hanaʻia

    Kahi inoa ʻO ka waiwai waiwai
    ʻIke kūpono (g / mol) 154.111
    Hoʻomākaukauʻo Isotope Atom 0
    Wahi Aʻe 41.1A '2
    Heluhelu Atomona Heavy 11
    XLogp3-AA -0.6
    Ka nui 173
    Hoʻokomoʻia ka papahana ʻAe
    Kāleka Kūikawā 0
    Ka Heluhelu Hoʻohālike Bond Bond 0
    Hoʻomākaukau'Āina Atom 0
    Ka helu helu hōʻemiʻole 0
    ʻO ka heluʻo Atom Stereocenter 0

    561314-57-6 Hōʻahoʻana

    2,8-Diazaspiro [4.5] decan-3-hoʻokahi kahi alana kuhikuhi.

    Ke alanui Kūʻai no 2,8-Diazaspiro [4.5] decan-3-hoʻokahi

    2,8-Diazaspiro[4.5]decan-3-one (561314-57-6)

    169206-67-1tert-Butyl 3-oxo ...

    6-Chloro-5-azaindole
    ~ 99%

    2,8-Diazaspiro[4.5]decan-3-one (561314-57-6)561314-57-6 2,8-Diazaspiro[4…

    2nd Kahi Kūlana

    2,8-Diazaspiro[4.5]decan-3-one (561314-57-6)

    945892-88-6 2,8-diazaspiro[4…

    6-Chloro-5-azaindole 2,8-Diazaspiro [4.5] <span data-mce-type =2,8-Diazaspiro[4.5]decan-3-one (561314-57-6)561314-57-6 2,8-Diazaspiro [4 ...

    Nā noi o 561314-57-6

    2,8-Diazaspiro [4.5] decan-3-hoʻokahi i hoʻohanaʻia ma keʻano he kikowaena i loko o keʻano o keʻano.

    2,8-Diazaspiro [4.5] decan-3-hoʻokahi mau hana lima palekana.

    1. 561314-57-6 Mana Mana Pūnaewele

    • Nānā 2,8-Diazaspiro [4.5] decan-3-one, 561314-57-6 i loko o ke kūlike me ka palekana palekana a me nā hana pilikino maikaʻi.
    • E hoʻohana i kahi kāhili hoʻolālā lāʻau i kēlā me kēia manawa e hana anaʻoe ma 561314-57-6.
    • E hōʻalo i ka hanaʻana i lepo a aerosols.
    • E hōʻoki i ka hanu hau, ka noe, ka lepo a me nā hihi.
    • E holoi lima lima i ka wā ma mua o ka haʻiʻana a ma hope o ka hana o hoʻokahi lā.

    2. 561314-57-6 Personal Personal Protection and Safety

    E paʻa mau i nā mea palekana e pono ke komo; nā pale umauma palekana, nā lole laulā a me nā mīkini pale lima.

    No ka pale pale

    • E hoʻohana i nā mīkina lima iʻikeʻia e pale i kou lima i ka wā e hana aiʻoe me 561314-57-6.
    • E hoʻomanaʻo mau i ka hahaiʻana i nā hawewe lima pono e kāpaeʻia; mai hoʻopa aku i ka ma waho o nā mīkina lima i hoʻokaheʻia e pale aku ai i ke kūʻana o kaʻili.
    • E mālama i nā hana maikaʻi a me nā kānāwai kūpono i ka hāʻawiʻana i nā mīkina lima i'ōwiliʻia.
    • E holoi holoi a maloʻo i nā lima.

    No ka pale a me ka pale

    • Pono e ho'āʻoʻia ka nānā maka maka a'āponoʻia e ke aupuni.
    • E hoʻohana i nā aniani mohala e loaʻa nā pale-ʻaoʻao e like me EN166.

    No ka mālamaʻana i ka hanu

    • E hoʻohana i ka P1 (EU EN 143) a iʻole e pipiʻi i ka PVNUMX (US) hauhā no ka meaʻino.
    • E hoʻohana i ka ABER-P2 (EU EN 143) a iʻole e kāwili i nā cartridges OV / AG / P99 (US) no ka palekana i kahi kiʻekiʻe o kaʻike.
    • Pono nā mea a pau a me nā breatpirators e ho'āʻo a'āponoʻia.

    3. 2,8-Diazaspiro [4.5] decan-3-hoʻokahi, palekana a me ka palekana.

    • Maiʻae i ka 561314-57-6 e komo i nā kahawai maʻamau.

    4. 561314-57-6 Nā mea hana mua

    Inā hoʻokomo a inu paha

    • Hoʻopi i ka waha me ka nui o ka wai no nā hola 15.
    • Eʻimi i ka lāʻau lapaʻau a me ka'ōlelo aʻo koke.

    No kaʻike maka

    • E hoʻopili koke i nā maka i ka nui o ka wai no nā hola 15 ke hāpai i nā pale umauma hema a me ka'ākau i ka manawa e hoʻomau aiʻoe i ka hoʻohui.
    • Eʻimi i ka palekana ke hoʻomau ka hōʻailona.

    Inā Inhaled

    • E wehe koke i ka mea maʻi mai kaʻikeʻole.
    • E lawe mai i ka mea hōʻeuʻeu i kahi ākea me ka lawaʻana o ka ea a i kahi lumi hoʻomaha maikaʻi.
    • E huli i ka lāʻau lapaʻau i ka manawa koke i nā hihia koʻikoʻi inā ua hoʻomauʻia ka maʻi.

    No ka Skin Contact

    • E hoʻomaʻemaʻe loa i ka wahi i hoʻopuniʻia me ka waiʻauwai a me ka'opaʻopa māmā.
    • E hele i kāu kauka a kauka lapaʻau inā e hoʻomau ka hōʻailona.

    5. E lawe i nā kumuhana hou ke hoʻohanaʻia me 561314-57-6

    • E mālama pono i ka hana maʻamau i ka pahu hana paʻa i ka 2,8-Diazaspiro [4.5] decan-3-one.
    • Lawe i kahi mea pale e hoʻopau ai i kahi pilina me ke kino.
    • E kāpae i ka hoʻokumuʻia o ka lepo a me ka aerosols.
    • E hōʻole i ka hoʻonui pinepine a lōʻihi i ka 561314-57-6 e like me ka hopena o ka hopena o ke kino i nā poʻe mahele.

    6. Ma hope o ka hoʻohanaʻana i 2,8-Diazaspiro [4.5] decan-3-one, e hōʻoia iāʻoe;

    • E hoʻopaʻa pono i ka pahu me ka huahana.
    • E hoʻihoʻi i ka pahu i kona pūnā mua.
    • E holoi a hoʻopau i kahi hana a laila eʻae i ka ea e holo i loko.
    • E wehe i nā loleʻaʻahu a me nā kāmaʻa i haumiaʻia; holoi i ka mea hoʻokahi ma mua o ka hoʻohana hou.

    7. Ināʻaeʻole ka hoʻohanaʻana o 561314-57-6, e nānā iāʻoe;

    • E kūʻai ma kahi maloʻo a maloʻo; e pale i ka wai.
    • E mālama i ka huahana i ka paʻaʻana mai ka poʻe iʻaeʻoleʻia.
    • E hōʻole i kekahiʻikeʻana i nā mea i kālaiʻoleʻia e like me; Acid anhydrides, Acid chloride, a me nā meaʻala a me nā mea hanaʻala.

    8. 2,8-Diazaspiro [4.5] decan-3-hoʻokahi Kūke a me ka lawelawe lima

    e lawelawe ana

    • Nānā i 561314-57-6 ma lalo o ka nānāʻana i ke kanaka kūpono; pono kaʻike o ke kanaka ma ke kūkōʻana i nā lāʻau lapaʻau kūikawā kūpono a me nā mea o ke olakino, nā ahi a me nā poino.
    • E kāpae i ka hoʻokumuʻia o ka lepo a me ka aerosols.
    • Maiʻae i ka pilina me nā maka a me kaʻili.
    • Makeʻa i ka hanuʻana i ka kino, ka lepo,ʻehu a me nā mokuahi.
    • E hoʻohana mau i ka papa hana palekana.
    • E hoʻohana i kahi hale hoʻumehana lāʻau.
    • E hōʻoia i ka nui o ka ventila i nā manawa a pau e hana ana me 561314-57-6.

    pūnaewele

    • Kālani 2,8-Diazaspiro [4.5] decan-3-hoʻokahi i hoʻopihaʻia i loko o nā moku i paniʻia.
    • Pono e huliʻia kahi wahi e mālama ai no ka paleʻana i nā mea hanaʻole.
    • E hōʻoia i ka hoʻolakoʻiaʻana o ka haweweʻana i kahi e mālama ai.
    • E mālama i ka 561314-57-6 ma kahi maloʻo a maloʻo.

    9. 2,8-Diazaspiro [4.5] decan-3-one, 561314-57-6 HōʻikeʻIkepili

    • E puhi i ka 561314-57-6 i loko o kahi mea puhi puhi lāʻau i hoʻokuʻuʻia me kahi ma hope o ka wela a me ke kāpili.
    • E makaʻala loa i ka hoʻololiʻana i kēia mea e like me 561314-57-6 he mea wela loa.
    • E hāʻawi i kekahi hanana kūpono a me nā hananaʻole i hoʻohanaʻia i kahi keʻena hana i'aikiniʻia.
    • Kāhea aku i kahi lālā hoʻolimalima hoʻolālā laikini kuhiʻia e kūʻai aku i kēia palapona waiwai.

    10. 2,8-Diazaspiro [4.5] decan-3-hoʻokahi Sensitivity a me Reactivity

    • E pale i nā huna ahi, nā ahi a me ka wela.
    • E mālama i ka 561314-57-6 mai nā mea hana uila.
    • E hōʻole i nā hopena hoʻomehana weliweli e like me nā mea'alapona'okena a me carbon monoxide.

    11. Nā 561314-57-6 Mea Pāʻani

    • Hoʻohui i nā mea mālama pono kūpono e kū ana i nā kūlana kūloko, federal, a me ka moku'āina a hana maikaʻi.
    • E hōʻoiaʻiʻoʻoe e uhi i kahi palekana a iʻole ka breatpirator i'āponoʻia.
    • E pale i kou mau lima ma ka hoʻohanaʻana i nā liʻiliʻi a me nā mīkina lima kūpono.
    • E pale i ka maka'ākau.

    Nā Hoʻomākaukau Kūʻai

    • Inā loaʻa ke ahi e pili ana i ka 561314-57-6 wale nō a iʻole me nā mea'ē aʻe, e hoʻohana i ka carbon dioxide, ka mīkini wai, ka mea hoʻokuʻu kūpaʻa a me ka maloʻo maloʻo e kinai ai.

    Pā'ā

    • E hoʻokuʻu me kahi'ūpoki'omaʻomaʻo e like me ke one a hoʻokuʻuʻia i ka hoʻohanaʻana i ka paila no ka hōʻiliʻiliʻana i ka'ōlohelohe i loko o ka pahu i hoʻopaʻaʻia no ka hoʻokuʻu.

    12. 2,8-Diazaspiro [4.5] decan-3-hoʻokahi, 561314-57-6 Nā Kiʻikuhi Hauula.

    • 561314-57-6 he meaʻeha ia i ka hopena no ka hopena o ka huhū o ka maʻi.
    • E mālama i ka hoʻonāʻauʻana o 561314-57-6 e like me ka hopena o ka huhū o ka hanu.
    • Maiʻae i ka nānā makaʻana me 561314-57-6 i mea e lilo ai ka maka i ka maka a me ka pōʻino.
    • E mālama i ka pilina me kaʻili ka mea e hoʻonā ai kaʻili o kaʻili.
    1. m)2,8-Diazaspiro [4.5] decan-3-one, 561314-57-6 Hoʻoponopono Kuleana
    • ʻAʻole nā ​​kumuhana a pau i loko o kēiaʻenehana i nā'ōlelo hōʻike i hoʻokumuʻia e ka SARA Title iii, Section 302.
    • ʻO ka CASʻAʻole i loko o kēia mea iʻoi aʻe ma mua o nā paepae hōʻike i hoʻonohonohoʻia e ka SARA Title, Paukū 313.
    1. n) 2,8-Diazaspiro [4.5] decan-3-hoʻokahi Shipping Shipping
    • 561314-57-6ʻoluʻoluʻole ia no ka holoʻana.
    • He palekana no ka laweʻana, ke ea a me ka lawe kaʻahele'āina.
    1. Kākoʻo Hanahana

    Heʻike a hoʻonui kā mākou pūʻulu i ka Material Science, Life Science, Ke Kaukini Huakini, Chromatography aʻoi aku.

    13. 2,8-Diazaspiro [4.5] decan-3-hoʻokahi 561314-57-6 Pūnaehana Bulk a me nā uku.

    Ponoʻoe i ka 2,8-Diazaspiro [4.5] decan-3-one, 561314-57-6 ma kahi nui? E kāleka i kā mākou kākoʻo kōkua no ke kōkua.

    ʻia ....................

    1. Tai, Vincent W.-F .; Garrido, Dulce; Price, Daniel J; Maynard, Andrew; Pouliot, Jeffrey J; Xiong, Zhiping; Seal, John W .; Kamalii, Katrina L; Kryn, Luz H .; Baughman, Todd M .; Peat, Andrew J. Bioorganic a me Medicinal Chemistry Letters, 2014, vol. 24, # 10 p. 2288 - 2294.
    2. Ke KōmikeʻOihana No ka'Ipele'Eolahana, US. Ka Hale Waihona Puke Lapaʻau, Pubchem, 2,8-Diazaspiro [4.5] decan-3-one, Māhele 1-10.
    3. Paul C.Fritch, Jeffrey Krajewski, Bioorganic & Medicinal Chemistry Letters Volume 20, Design, syntheses, and SAR of 2,8-diazaspiro [4.5] decanones as antagonists channel T-type, 6375-6378 mau palapala
  2. Apicmo -

    ʻO ka 2,8-Diazaspiro maikaʻi loa [4.5] decan-3-hoʻokahi a me ka lawelawe i loaʻa iaʻu,ʻike maikaʻi.

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