4-Chloroquinazoline (5190-68-1)

(2 Customer hōʻike manaʻo)

Ke noho nei kēia huahana ma kahi palapala pāʻani APICMO.

Ka hiki ke hana, synthesi a hana i nā mea nui o ka 4-Chloroquinazoline (5190-68-1) me ka pūnaewele maikaʻi ma lalo o ka CGMPʻoihana
nā kauā.

Māhele:

Description

4-Chloroquinazoline (5190-68-1) wikiō

Ua hoʻolālāʻia kahi hua'ōlelo hou o 4-hetroaryl i paniʻia a quinazolines a hoʻohuiʻia e ka hopena o ka pentafluoro (chloro) pyridine a me ka 2-substituted quinazolinone. ʻO ka substitutional aromatic nucleophilic o ka pentafluoro (chloro) pyridine me ka quinazolinone e hanaʻia ma ka 4-kahi o ke pyridine mama e ka oxygen pūnaewele (O-centered nucleophile) o quinazolinone. ʻO nā hanana o nā pūpū a pau i hoʻopaʻaʻia e IR, 1H NMR, 19F NMR, a me ka spectroscopy 13C NMR a me ka hoʻoʻiliʻili o nā elemental.

ʻO ka hapa nui o nā huahana synthesized i hōʻikeʻia i ke kūponoʻole i nā hanaʻoi aku antiproliferative e pili ana i nā lālani pūnaewele tumalima maʻamau. I huiia 8d hōʻike i ka loa kupaianaha inhibitory hana ku eʻeho keena hōʻike hihiu type (A431, A549 a me SW480 aeee) ole mutant (HCC827 a me NCI-H1975 aeee) epidermal ulu ololi mea loaʻa (EGFR) (me IC50 aiee ma ka laulā o 0.37-4.87 μM), a me nā hopena hopenaʻoi aʻe o ka hopena e pili ana i ka EGFR tyrosine kinase hou (EGFR-TK, wt a T790M) (me nā helu IC50 o 7.0 a me 9.3 nM). ʻO ka hana i ka molecular show that 8d hiki ke hoʻohui i nāʻehā waihā me ka EGFR, aʻelua o lākou i loaʻa ma ka asp855-Phe856-Gly857 (DFG) kumu o EGFR. I kēia manawa, hiki i ka 8d ke kahakaha i ka hoʻouluʻana o ka EGFR i ka EGF a me ka phosphorylation o kona mau protein ma lalo e like me Akt a me Erk1 / 2 i nā pūnaewele NSCLC kanaka. Eia kekahi, 8d i paniʻia i ka apoptosis pūnaewele a me ka lōʻihi o ka piʻiʻana o ke kamepiula ma G0 / G1-phase ma nā pūnaewele A549. He hana kupanaha ka hana no ka hoʻonui a hoʻoikaika i nā mea hoʻonāukiʻole o ka MAGGR tyrosine kinase (TKI).

4-Chloroquinazoline (5190-68-1) Hōʻike

CAS 5190-68-1
Ke kaʻina CAS% 95.0
Kālena CAS Max% 100.0
MDL Number ʻO MFCD00228682
InChI Key GVRRXASZZAKBMN-UHFFFAOYSA-N
Ka inoa inoa inoa 4-Chloroquinazoline
Pāʻani infrared pono
ʻO ke Kino Liquid
'ōpala ʻO ka'ōmole Glass
Ka Lā Molecular C8H5ClN2
Molecular Weight (g / mol) 164.6
SMILES C1 = CC = C2C (= C1) C (= NC = N2) Cl
kala like 'ole Eʻikeʻole i kaʻeleʻele i ka wai'ōmaʻomaʻo
Point Hoʻolālā 96-100 ° C
ʻAna 97%

4-Chloroquinazoline (5190-68-1) Mālama a mālama

(5190-68-1) Hōʻikeʻikepili:

ʻO nā'āpana'ōpala APICMO

♦ Makeʻona inā 'ai.

♦ Hiki ke make i ka lolie a komo i nā alaloa.

♦ Hana i nā meaʻinoʻino maka.

♦ E hoʻoweliweli i ka hanu hau.

ʻO 4-Chloroquinazoline'ōlelo kūkala'ōlelo:

♦ Aloʻa i ka hanuʻana i ka lepo / fume / gas / mist / vapors / spray.

♦ Wear pale pale lima / pale pale / pale maka / pale pale.

♦ I KA PALAPALA: E kāhea koke aku i kahi POISON CENTER a kauka / kauka.

♦ I KA IE EESE: E hoʻoponopono me ka nānā me ka wai no nā minuke. Wehe i nā leka hulina, inā he mau a hiki ke maʻalahi.

'Ōlelo Aʻo: Ua hoʻokumuʻia kaʻike i hoʻolakoʻia ma kēia pūnaewele e like me nā kānāwai o ka Europa (EU) a ua kūpono i ka maikaʻi o ko mākouʻike, kaʻike a me ka manaʻo i ka lā o kona hoʻolahaʻana. ʻO kaʻike i hāʻawiʻia i kūkuluʻia wale nōʻo ia ke alakaʻi no ka mālama pono a hoʻohanaʻana. ʻAʻole pono e noʻonoʻoʻia e like me ke kikowaena a iʻole ke kiko kiko'ī.

4-Chloroquinazoline (5190-68-1) Nā'Ōlelo

Nānā i ka hanaʻana o kekahi mau Quinazolinones i hoʻohuiʻia me Pentafluoro (chloro) pyridine

Ua hoʻolālāʻia kahi hua'ōlelo hou o 4-hetroaryl i paniʻia a quinazolines a hoʻohuiʻia e ka hopena o ka pentafluoro (chloro) pyridine a me ka 2-substituted quinazolinone. - [Keʻena Hua'ōlelo Hua'ōleloʻo Lymic acid 2018 vol. 55 # 2 p. 475 - 480]

6,7-Dimorpholinoalkoxy quinazoline mau huapalapala e like me nā mea hoʻolālā kūwaho o ka EGFR me nā hana hana antiproliferative e kū'ē i nā pūliko tumora

ʻO ka hapa nui o nā huahana synthesized i hōʻikeʻia i keʻano kūponoʻole i nā hana antiproliferative hana e pili ana i nā līlū maʻamau maʻamauʻelima o ke kanaka .- [European Journal of Medicinal Chemistry 2018 vol. 147 p. 77 - 89]

Nānā Hanahana:

Loaʻa kaʻike o kā mākou pūʻuluʻepekema ma nā wahi noiʻi a pau e pili ana i Life Science, Material Science, Synthesis Chemical, Chromatography, Analytical a me nā mea'ē aʻe.

4-Chloroquinazoline (5190-68-1) Pāʻani Kauoha & Pricing:

Loaʻa i nā mea nui no kāu kūkuluʻana, hana hana a noiʻi noiʻi paha?


=

Additional 'ike

nā mea wehewehe Hōʻike

APICMO hana a hāʻawi i ke olonā i Nine Inch me kona mea e like oe ke helu i a me ka poe me CAS helu 27631-29-4, oe hiki ke hoomauia ia a pau 2,4-Dichloro-6,7-dimethoxyquinazoline huahana mohai aku e pae, halawai a oi aku i ka papa 'koi a hoakaka no kēlā me kēia huahana.

2 hōʻike manaʻo no ka mea, 4-Chloroquinazoline (5190-68-1)

  1. APICMO -

    Ponoʻoe e lako i nā mea nui a nui paha o ka 4-Chloroquinazoline 5190-68-1 iʻoi aku ke kiʻekiʻe loa? Mai nānā hou aku, hiki iā mākou ma APICMO ke synthesize, hana a hana i nā mea nui 4-Chloroquinazoline ma waena o nā meahana'ē aʻe.

    ʻO nā huahana a pau o nā koina loa loa ke hoʻokō pololei loa i nā kānāwai CMPG a pau i ka mana maikaʻi a me nāʻoihana hana'ē aʻe.

    He aha nā Quinazolines?

    Aia ka 4-Chloroquinazoline ma ka papa quinazolines. He mea nui loa ka Qumazolines i ka wā e hele ai i ka mea lapaʻau. Hoʻonohonohoʻia lākouʻo ka pūnaewele heterocyclic. Kūkuluʻo Quinazolines i nā mea ola honua āpau e hiki ai iā lākou ke hana e like me; ka anti-inflammatory, anti-fungal, anti-bacterial, anti-tuberculosis, anti-viral, anti-malarial, anti-cancer, anti-HIV and also has a analgesic ability.

    4-Chloroquinazoline 5190-68-1ʻOhana Kino

    5190-68-1 CAS

    [Caption ka memo a = "attachment_724" align = "alignnone" laula = "600"]4-Chloroquinazoline kaheʻe (5190-68-1) -APICMO 4-Chloroquinazoline kaheʻe (5190-68-1) -APICMO [/ kiʻi kiʻi]

    4-Chloroquinazoline 5190-68-1 Applications

    5190-68-1 wale nō e hoʻohanaʻia no ka noiʻi a me ka hoʻolālā. Eia kekahi, pono e hoʻohana ponoʻia e ka poʻe akamai a iʻole ma lalo o kā lākou nānāʻana. 4-Chloroquinazoline 5190-68-1 Synonyms

    Loaʻa nā inoa likeʻole i ka 4-Chloroquinazoline 5190-68-1, a ua komo lākou; 4-Chlorchinazolin, 4-Chloroquinazoline, Quinazoline, 4-chloro- (8CI) (9CI), 4-Chloro quinazolines, Quinazoline, 4-chloro, 4-chloro-quinazoline a me nā mea hou aku.

    4-Chloroquinazoline ma ka 'ano like; nā kahe heterocyclic blocks, ke kiʻi mele, nā heterocycles halogen, nā papa hale, a me nā quinazolines.

    4-Chloroquinazoline 5190-68-1 Nā Kino a me Nā Pono Kino

    Loaʻa ka'ōhumu molikino o C8H5CIN2,ʻo 5190-68-1 ka nui o ka nui o 164.014 g / mol a me ka kaumaha kaulike o 164.592 g / mol. Loaʻa iā ia heʻelua'āpana'āpana a he nui o 1.349 g / cm3.

    ʻO ka pae hoʻoheheʻe ke kauʻia mai ka 96-100 kiʻekiʻe Celsius me ka paila kola o ka 281 kiʻekiʻe Celsius ma ka 760 mmHg. ʻO ka helu kuhikuhi hoʻomanaʻoʻo 1.662 a me PSA o 25.78000.

    5190-68-1 ke hele mai i loko o ka puka wai a heʻoluʻolu ke nānāʻole i ka'ōlena'ōmaʻomaʻo i kaʻoni.

    4-Chloroquinazoline 5190-68-1 Hōʻaho Kūpuna

    5190-68-1 hiki ke hoʻouluuluʻia i ka 11 mau ala likeʻole kekahi o ia mau mea;

    4-Chloroquinazoline 5190-68-1

    4-Chloroquinazoline 5190-68-1 Pūnaewele i hoʻohuiʻia

    Kahi inoa ʻO ka waiwai waiwai
    Hoʻohana Hoʻolaha Huawai'Ila 2
    Ka nui 140
    Purity 97%
    XlogP3 1.9
    Wahi Aʻe 25.8A '2
    Kāleka Kūikawā

    0
    Heluhelu Atomona Heavy 11
    Hoʻomākaukauʻo Isotope Atom 0
    Pāleka hiki ke hoʻololiʻia 0
    ʻO ka Covalent Bond Unit Count 1
    Ka Waihona Waiwai Bond 0
    Monoisotopic Mass (g / mol) 164.014
    Kālepa CACTVS Pūnaewele Pālua AAADCYBZAAAEAAAAAAAAA
    AAAAAAAAAAAAAA89ACx8AA
    AHAIAAAAADAqBHiQ10PYIE
    AcgAyRjZAccgckxBqAJ2Ca4zpi
    Kākākūkā
    OAAAAAAAAAAAAAAAAAAQ
    AAAAAAAAAAA
    Hoʻomākaukau'Āina Atom 0
    Hoʻonohonohoʻia ka papahana Stereo Helu 0
    Hoʻopukaʻia kahi Atom Streo center Count 0
    Ke kuhi helu hoʻokūkūʻo Bond 0

    4-Chloroquinazoline 5190-68-1 Nā Kiʻikuhi Hauula

    ʻO ke kūʻokoʻa kūpono o 4-Chloroquinazoline me kaʻili e hiki ai i kaʻili keʻiliʻia a me ka palaʻino. E hoʻohana i nā kapa pale i ka manawa e mālama aiʻoe i kēia huahana.

    Hiki i ka 5190-68-1 keʻawaʻawa i ka wā e hoʻokomoʻia ai, hiki i ka make inā make. E hōʻole i kaʻaiʻana, ka inu a me ka puhiʻana i ka pumeʻana i ka lawelaweʻana me kēia huahana.

    Mai hoʻoneʻe a hoʻomaha paha i ka 4-Chloroquinazoline e like me kēia e hoʻonāukiuki ai i ka'ōhū o ka'ōhū a hoʻoneʻe i ka mea ino o kēlā mehe kiko'ī. Hiki paha i ka maʻi ke komo i loko o nā ala i ka hanuʻana a iʻole ka inhaled.

    Hiki ke hoʻokae i ka maka i nā maka a me nā maka.

    Nā pilikia kūikawā kūpono no ka 4-Chloroquinazoline i loko; Hoʻohuheʻe hauwai, carbon dioxide, a me Nitrogen Oxides.

    4-Chloroquinazoline 5190-68-1 Nā mea hana mua

    No Kiko

    Ināʻikeʻole kou mau maka i ka 5190-68-1, e wikiwiki e huki i ka wai kūpono. ʻOiai e hana ana i kēia e hoʻokiʻekiʻe i nā'ōpū ma luna a me nā puʻu haʻahaʻa mai kēlā manawa i kēia manawa e hoʻomaʻemaʻe i kahi holoi holoi.

    Inā loaʻa nā leka hulina a maʻalahi e wehe, e hana pēlā i ka hoʻomauʻana i ka holoi. Eʻimi koke i ka lāʻau lapaʻau a iʻole e hea i kahi kikowaena i loko.

    No ka pololei o ka pehu, e holoi i ka ili i hoʻopiliʻia me ka nui o ka wai e hoʻohana ana i kahi'ōponi moa no nā hola 15 i kāu weheʻana i nā lole a me nā kāmaʻa i haumia. Eʻimi i ka lāʻau lapaʻau i ka wā hiki loa aiʻole e kāhea i kahi pokapū make. E hoʻomanaʻo i ka holoiʻana i nā lole a me nā kāmaʻa i kāpaeʻia ma mua o ka hoʻohana houʻana.

    No ka Inhalation

    Inā hoʻomaha a X inhauma ka 4-Chloroquinazoline aiʻole e komo i loko, e wehe koke i ka mea i loaʻa mai ka hōʻailona. E lawe mai i kahi mōhai i kahi ākea me ka ea hou a kahi lumi hoʻomaha maikaʻi. E kau iā ia ma kahiʻoluʻolu mai kahi'ākau eʻoluʻolu ai i ka hanuʻana.

    Hiki iāʻoe ke lawelawe i ka hoʻohemoʻana i ka hanaʻana kahiʻoi aku ka paʻakikī a ua pani paha. Mai hoʻomanaʻo i ka ho'āʻoʻana i ka waha i ka hanu i kahi e komo ai nā kinikino. ʻO ka hope, e nīnau i ke kauka aiʻole kauka; Hiki iāʻoe ke kapa aku i kahi kikowaena lāʻau.

    ʻAina

    Ināʻoe a iʻole kekahi mea e hoʻonele a hoʻoneʻe paha i ka 4-Chloroquinazoline, holoi i ka waha me ka nui o ka wai no nā hola 15. Mai ho'āʻo e hoʻokuʻu i ka luaʻiʻole ke'ōleloʻoleʻia e ke kahu mālama ola e hana pēlā no ka mea e hoʻonāukiha paha kēia.

    Mai ho'āʻo e lawelawe i kekahi mea me ka paneʻole ināʻaʻole maopopo kaʻikeʻole. E loaʻa i ke kākoʻo mālama ola mai ka manawa ā hiki a kahea paha i kahi pokapū make ma kou wahi.

    4-Chloroquinazoline 5190-68-1 Mea lawelawe lima a me kahi mālama

    5190-68-1 Manaʻo

    5190-68-1 pono e mālama ponoʻia e kekahi mea akamai a ma lalo paha o kā lākou hoʻomākaukau. Ke hoʻohanaʻia, e hoʻomanaʻo e noʻonoʻo i nā pōʻino o ke olakino, nā ahi a me nā meaʻino e like me ia i hōʻikeʻia ma ka pepaʻikepili i hāʻawiʻia.

    E hoʻomanaʻo mau e hoʻolālā i ka manawa kūpono me kēia huahana i nā mea a pau āu e hiki ai. E hōʻoiaʻiʻo iāʻoe he mea mālama pono piha ma mua o ka hoʻohanaʻana i kēia huahana e pono e komo;

    • ʻO nā pale pale maka e like me nā pale pale pale e kū'ē i nā kinikona me kahi pale pale e pale i kou mau maka a ke alo mai kahi kūkā pū me kēia huahana.
    • E lawe i nā manunuhi a me nā manamana limaʻole i nānāʻia ma mua o ka hoʻohanaʻana e pale i kou mau lima mai kahi pilina pololei me kēia huakiko. E kūpono nā mīkina lima i nā mea hana. E hoʻomanaʻo mau i ka weheʻana i nā mīkina lima me ka hoʻopiliʻana i kona kua. E wehe i nā mīkina lima i hoʻohanaʻia no ka mālamaʻana i nā rula o nā kaiāulu, kūloko a me nā aupuni.
    • E hoʻohana i nā kāmeka respirator P2 paha a iʻole ka mask i'āponoʻia e hōʻoiaʻaʻoleʻoe e hanu a hoʻolālā paha i ka 4-Chloroquinazoline.

    E mālama i ka lepo a me ka aerosols i ka hanaʻana me kēia huahana. E uhi i kou ihu me ka huna lepo. E hoʻohana mau i ka hopena kalakino i ka hanaʻana me kēia mekino a me ka hoʻomaopopoʻana i ka maikaʻi o ka'āpana.

    E holoi lima mau i kou mau lima ma mua o kou heleʻana no ka wāwahi a ma hope o kāu lā hana. E holoi i kou kino ma hope o ka lawelaweʻana i kēia huahana no ka olakala pilikino.

    Maiʻae i ka holoʻana o 5190-68-1 i loko o nā waiwai wai aiʻole laina laina. Inā hōʻahaʻia, e hoʻohui i kēia huahana me kahi meaʻona inerā e like me ke one a laila e hōʻiliʻili i loko o kahi pahu momona a pili pono i mua o ka hoʻokuʻu.

    4-Chloroquinazoline 5190-68-1 Pūnaewele

    E hoʻopili pono i nā pahu a paʻa i kahi paʻa ma kahi kaʻawale mai nā poʻe iʻaeʻoleʻia. E kūʻai i ka huahana ma kahi maloʻo a maloʻo kahi e palekana ai. E like me ka mea i hōʻike muaʻia, e pale i nā mea hana kūpilikiʻi weliweli e like me hydrogen chlorides, carbon monoxide, a me nā meaʻaila.

    4-Chloroquinazoline 5190-68-1 Ke Kaua Keʻena Kaua

    Inā loaʻa ke ahi e pili ana i kēia huahana a iʻole iʻole me nā mea'ē aʻe i waho; e hōʻoiaʻiʻoʻoe e kau i ka papa hana palekana i'āponoʻia a me nā mea e hoʻomaha ai i loko o kou kino ma mua o kou hoʻomakaʻana e hakakā i ke ahi.

    E hoʻohana i ka carbon dioxide, ka maloʻo maloʻo, ka mea hoʻonāwaʻaka a me ka wai. Mai hoʻohana i kahi wai e hoʻopau i ke ahi e pili ana i kēia huahana. E hōʻoia mau e mālama i kahi mamao mamao mai ke kinaiʻana i ke ahi.

    4-Chloroquinazoline 5190-68-1 Pūnaeho Haʻawina

    E hoʻokuʻuʻia kēia huahana e like me kahi kūlana kūikawā kūlike i nā kūlana kūloko a me nā moku āpau. Hiki iāʻoe ke hoʻonohonoho no ka hōʻiliʻiliʻana mai kahi lālā laikini a laikiniʻia ma hope o ka nīnauʻana i kāu mana hoʻokuʻu kūloko. A eia kekahi, hiki iāʻoe ke puhi i kēia huahana i loko o kahi mea hoʻonā i hoʻonohonoho ponoʻia me ka gas flue a me kahi kāpili. E makaʻala i ke kinakiʻana i kēia huahana no ka mea he mea wela loa e pale i kahi pōpilikia.

    E hāʻawi aku i nā keu o nā mea hanaʻole. E huiʻekolu i nā pahu hakahaka no ka hana hou a me ka hoʻouka hou. Hiki nō paha iāʻoe ke koho i ka punukiʻana i nā pahu hakahaka i mea e hikiʻole ai ke hoʻohanaʻia no ka hoʻohanaʻana i ka wā e hiki mai ana.

    4-Chloroquinazoline Ka Pono a me ka Hoʻouka Hana

    5190-68-1 kūpaʻa mau i ka mālamaʻana i nāʻano i'ōleloʻia. E hōʻalo i ka hoʻonāʻana i nā kapuahi ahi, ka lapalapa, a me ka wela. E mālama i nā huapalapala kūpilikiʻi weliweli e like me nā waiūpona'okena, hydrogen chloride, a me carbon monoxide.

    4-Chloroquinazoline 5190-68-1 Palapala Pāʻoihana

    ʻO ka inoa o ka moku kūpono he meaʻawaʻawa, Organic, N_O_O_ (4-Chloroquinazoline). Aia i ka Class 6.1, Packaging Group III aʻo ka UN UN ka UN 2811.

    4-Chloroquinazoline 5190-68-1 Palapala Hōʻike

    ʻAʻole nā ​​mea hana a pau i loko o kēiaʻenehana e hōʻike i nā rula i hoʻonohoʻia e ka SARA Title III, Section 302. ʻO nā helu CASʻaʻole lākou iʻoi aku ma mua o nā pae hōʻike paepae i hoʻokumuʻia e ka SARA Title III, Section 313.

    Kākoʻo Hanahana

    Ma Apicmo, ke hoʻokiʻekiʻe nei mākou iā mākou iho i loko o ko mākou pūʻulu o ka poʻe akamai i loaʻa iā lākou kaʻike i loko o ke Kauka Huapīpī, Life Science, Analytical Science, Material Science, Chromatography a me nā mea'ē aʻe.

    4-Chloroquinazoline Bulk Hoʻonohonoho a me nā uku

    Inā makemakeʻoe i nā mea nui o ka 4-Chloroquinazoline 5190-68-1 no ka noiʻi, hoʻolālā a hana paha; e hoʻopili aku me kā mākou hui o ka mālamaʻana i ka lawelaweʻana i ka pilina a me ka lokomaikaʻi, a na mākou e hoʻopuka i kāu kauoha ma keʻano pololei a me ka manawa e pono ai.

    ʻia ....................

    1. Ham, Young Jin; Lee, Duck-Hyung; Choi, Hwan Geun; ʻO lākou,ʻo Jung-Mi; ʻO Sim, Taebo Tetrahedron Letters, 2010, vol. 51, # 35 p. 4609 - 4611
    2. Myers, Michael R ;; Setzer, Natalie N .; Spada, Alfred P .; Zulli, Allison L; Hsu, Chin-Yi J; Zilberstein,ʻAsera; ʻO Johnson, Susan E .; Hook, Linda E; Jacoski, Mary V. Nā lāʻau olaola, a me nā lāʻau lapaʻau kino Palapala Letters, 1997, vol. 7, # 4 p. 417 - 420
    3. Ke KōmikeʻOihana No ka'Ipele'Eolahana, US. Ka Hale Waihona Puke o ka Hale Waihona, PubChem, 4-Chloroquinazoline, 5190-68-1 Mahele 1-9.

  2. Apicmo -

    ʻO 4-Chloroquinazoline maikaʻi loa a me ka lawelawe i loaʻa iaʻu,ʻo kaʻike maikaʻi

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