ʻO Monosialotetrahexosylganglioside Sodium (GM1) puaʻa puaʻa (37758-47-7)

(1 Customer manual)

Ke noho nei kēia huahana ma kahi palapala pāʻani APICMO.

ʻO ka hiki ke hana, synthesize a hana i nā mea nui o ka lolo o ka monualotetrahexosylganglioside Sodium (GM1) (37758-47-7) me ka pūnaewele maikaʻi ma lalo o ka CGMPʻoihana
nā kauā.

Māhele:

Description

Monosialotetrahexosylganglioside Sodium (GM1) puaʻa puaʻa (37758-47-7) Hōʻike

He mau mea nui o Gangliosides o nā membrane cell neuronal a me ke reticulum endoplasmic. Aia lākou i loko o kahi kaula polysaccharide maʻamau i pili pū me ka ceramide ma o ka pilina β-glycosidic.

ʻO Galactosidases nā enzymes i hāʻule GM1. ʻO GM1, ka mea i kapaʻiaʻo monosialotetrahexosylganglioside,ʻo ia ka "prototype" ganglioside, he lālā o ka series ganglio o nā gangliosides i loko o kaʻeha hoʻokahi sialic. ʻO GM1 he mau waiwaiʻano physiological kūikawā a me nā hopena o keʻano palekana a me nā hana hou, a me ka hoʻokuʻuʻiaʻana o nā neurotrophins ma ka lolo. Ma waho aʻe o kāna hana ma ka physiology o ka lolo, hanaʻo GM1 i ke kahua o ka hoʻopaʻaʻana no ka cholera toxin a me E. coli wela-labile enterotoxin (ka maʻiʻana).

Ke noho nei kēia huahana ma kahi palapala pāʻani APICMO. Ināʻikeʻoe i kēiaʻaoʻao ma keʻano he mea hoʻohanaʻoleʻia,ʻo ke kumukūʻai i hōʻikeʻia he List Price. No kaʻikeʻana i kāu kumukūʻai, e hoʻopaʻa i ka hoʻohanaʻana i kāu helu helu, aiʻole e liloʻoe i mea hoʻohana inoaʻia e ke kākoʻoʻana i kahi o kā mākou hui lawelawe. No ka hoʻonohonohoʻana i kahi kauoha, e hoʻopili i kahi lawelawe o ka APICMO.

ʻO Monosialotetrahexosylganglioside Sodium (GM1) puaʻa puaʻa (37758-47-7) Hōʻike

CAS 37758-47-7
Ke kaʻina CAS% 95%
Kālena CAS Max% 100%
MDL Number ʻO MFCD00466936
InChI Key QPJBWNIQKHGLAU-IQZHVAEDSA-N
Ka inoa inoa inoa Monosialotetrahexosylganglioside Sodium (Kalikimaka), GM1
Pāʻani infrared pono
ʻO ke Kino ka lehu
'ōpala /
Ka Lā Molecular C73H131N3O31
Molecular Weight (g / mol) 1546.841
SMILES Kālepa Kūkākūkā o CCCCCCCCC ((O O) NC (COC1C (C (C (C (O1) CO)
OC2C(C(C(C(O2)CO)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)
CO) O) O) O) NC (= O) C) OC5 (CC (C) (C (O5) C (C (CO) O) O) ((O)
C) O) C (= O) O) O) O) O) C (C = CCCCCCCCCCCC) O
kala like 'ole Kūleʻele a iʻole keʻokeʻo
Point Hoʻolālā 207-230ºC
ʻAna 98%

Nā mea ho'āʻo I loko o ka hale Pono Standards
Cka mea hōʻailona Pahuʻeleʻele aʻeleʻele paha; pume iki,ʻono; ū. Hiki keʻoluʻoluʻia kēia huahana i loko o ka wai, kahi liʻiliʻi loa i ka methanol, kahi kokoke i ka welaʻole i ka hanano anhydrous.
Kaʻike
Hana hoʻopiʻi hoʻopiʻi 1 E hoʻoholo i ka hopena hōʻoia 0.2ml ma lalo o ka manaʻo hoʻoholo, e hoʻohui i ka wai 2ml, a laila hoʻohui i ka waiuma wai hydrochloric acid (hydroquinone 0.2g, e hoʻohui i ka wai o 10ml, e hoʻohui i ka waiuma 90ml, e hoʻohui i ka 0.1mol / L Copper sulfate solution 0.25ml, mālama mālama pumehana) 2ml, ka wai holoi hoʻolālā no nā 15 minuke, kaʻoluʻolu blue a me ka poni, me ka meaʻawaʻawa 5ml ka hoʻonaninaniʻana,ʻo kaʻeleʻele inu lama he uliuli.
Hana hoʻopiʻi hoʻopiʻi 2 E hoʻohui i kēia huahana e pili ana i ka 20mg, e hoʻohui i ka waikiko wai maloʻo 1ml, e hoʻomaʻemaʻe loa i ka wai holoi wai nui, e hoʻonui iʻekolu kelehe lahilahi 1, ma ka wai holoi wela ma ka paia pani e hoʻonui i ka sulfuric acid 1ml, i hiki ai i ka hopena iʻelua papa , he meaʻeleʻele ka lihiʻelua-wai
ʻO ka paʻakai sodium ʻO ka hōʻailonaʻike o ka paʻakai sodium i kēia huahana (ʻo ka Chinese Pharmacopoeia 2015 ka unuhiʻehā 0301).
ʻO ka chromatography huawai (LC) Ma ka pakuhi papapili palapala i kākauʻia ma lalo o ka manaʻo hoʻoholo i ka manaʻo, e kūlike ka manawa kūpaʻa o ka pehi nui o ka hopena hōʻoia me ka manawa kū o ka peakena nui o ka hopena mana.
Pākuʻi pāʻaniʻole ʻO ka palapala hōʻaihoʻikepiliʻeha o kēia huahana e kūlike me ka palapala'āina o ka huahana (ʻo ka Chinese Pharmacopoeia 2015 versionʻehā 0402).
ʻImi
PH 5.0 ~ 6.5
ʻO ke kūpono a me ke kala o ka hopena Pono e hoʻokaʻawale i kaʻikeʻole; ināʻeleʻele,ʻaʻole ia eʻoi aku ka mānoanoa ma mua o ka wai maʻamau o ka ululāʻau NĀ 1th; Ināʻaʻole iʻoi aku ka hohonu o ka pena ke kala ma mua o ka solution Yellowimeter 1th colorimetric.
Ka manaʻo hoʻoholo kiʻekiʻe Pono e wehewehe a wehewehe ka hopena i hoʻopauʻia ma hope o ka mahana wela,ʻaʻohe waiū o ka wai,ʻaʻohe pakele
Nā kumu Sensitizing (Miscellaneous protein) ≤50000
Ka nui o Sialic acid E like me ka heluʻana o ka huahana maloʻo,ʻo kaʻepa i loko o ka waipaʻa he 19.0 ~ 21.0%
Nā mea pili Sialic acid ≤0.3%; GD3, GD1a, nā mea haumia iʻikeʻoleʻia he ≤ 0.5%; nā meaʻino a me ka ≤2.0%
kumuʻiʻo ≤1.0%
ʻO nā haumiapela kaumaha nui ≤0.5%
Nā hopena palekana Methanol ≤ 0.1%; acetone ≤ 0.3%; Trichloromethane ≤0.003%
ka wai ≤4.0%
ʻO ke koena ≤5.0%
Heavy metal ≤20ppm
ʻO nā meaʻino kūlohelohe Nā rula mālama
Nā mea'alopīpī Pono e like me nā rula (nā nui o ka hoʻomalu)
ʻO Pyrogen Pono e like me nā rula (nā nui o ka hoʻomalu)
ʻO nā palena pāpili ʻO ka nui o nā hua bacteria e pono ai ke <100cfu / g, aʻo ka helu helu o nāʻele a me nā lehelehe e lilo i <50cfu / g
Kūkoʻa ≥98.0%

ʻO Monosialotetrahexosylganglioside Sodium (GM1) puaʻa puaʻa (37758-47-7) Haumaru a Hoʻoponoponoʻana

Hōʻike GHS H

  • H318-H302-H335-H315
  • Hana i nā meaʻinoʻino.
  • ʻO kaʻinoʻino ināʻeha.
  • Hiki ke hoʻonāukiuki i ka hanu hau.
  • Hana i ka huhūʻili.

Kōkā'ōlelo GHS P

  • P261-P280-P305+P351+P338-P304+P340-P405-P501a
  • Makeʻa i ka hanuʻana i ka lepo / fume / gas / mist / vapors / spray.
  • Wewe pale lima pale / pale pale / pale maka / pale pale.
  • KA HANA I KA EYES: Hoʻoholo me ka nānā me ka wai no nā minuke. Wehe i nā leka hulina, inā he mau a hiki ke maʻalahi. E hoʻomau i ka holoi.
  • KA INHALED: E hoʻoneʻe i ka ea ea e hoʻomaha i ka wahi kūpono no ka hanuʻana.
  • E kūʻai i ka mea i hoʻopaʻaʻia.
  • Hoʻokaʻawale i nā mea / ipu me nā kūlana o ka moku / ka 'āina / aupuni / ka honua.

'Ōlelo Aʻo: Ua hoʻokumuʻia kaʻike i hoʻolakoʻia ma kēia pūnaewele e like me nā kānāwai o ka Europa (EU) a ua kūpono i ka maikaʻi o ko mākouʻike, kaʻike a me ka manaʻo i ka lā o kona hoʻolahaʻana. ʻO kaʻike i hāʻawiʻia i kūkuluʻia wale nōʻo ia ke alakaʻi no ka mālama pono a hoʻohanaʻana. ʻAʻole pono e noʻonoʻoʻia e like me ke kikowaena a iʻole ke kiko kiko'ī.

Articles

ʻO Ganglioside GM1-hiki i ka transcytosis o ke cholera kaxo ma ke alahele o kaʻaoʻao retrograde a ke hilinaʻiʻia ma keʻano o ka papa ceramide.

ʻO Biol. ʻO Chem. 288 (36), 25804-9, (2013)

ʻO ka Cholera pēpē ke kumu i ka maʻi diarrheal ma ke kāʻeiʻana i ka GM1 ma luna o ka membrane apical o nā epithelial pūpū meheu a me ka retrograde pūnaewele i nā hopena o nā endosomes, ka trans-golgi ...

ʻO ka maʻi amyloid-peptide maʻi o Alzheimer e pili ana i ka nui-dynamics o nā loft-mimicking Lo mau inoa ma GM1-lipid bilayers.

Staneva G, Puff N, Stanimirov S, Tochev T, Angelova MI, Seigneuret M.

Nā meaʻoluʻolu. 2018 Dec 5; 14 (47): 9609-9618. hana: 10.1039 / c8sm01636d.PMID: 30457145

Monosialotetrahexosylganglioside Sodium (GM1) puaʻa puaʻa (37758-47-7) Keʻena Hana Hana Hana:

Loaʻa kaʻike o kā mākou pūʻuluʻepekema ma nā wahi noiʻi a pau e pili ana i Life Science, Material Science, Synthesis Chemical, Chromatography, Analytical a me nā mea'ē aʻe.

ʻO Monosialotetrahexosylganglioside Sodium (GM1) puaʻa puaʻa (37758-47-7) Kūlana Hoʻopuka & Pricing:

Loaʻa i nā mea nui no kāu kūkuluʻana, hana hana a noiʻi noiʻi paha?


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1 manual no ka mea, ʻO Monosialotetrahexosylganglioside Sodium (GM1) puaʻa puaʻa (37758-47-7)

  1. Keʻena Luna -

    ʻO Monosialotetrahexosylganglioside ka maikaʻi (GM1) a me ka lawelawe i loaʻa iaʻu,ʻike maikaʻi.

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