7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

(2 Customer hōʻike manaʻo)

Ke noho nei kēia huahana ma kahi palapala pāʻani APICMO.

Ka hiki ke hana, synthesi a hana i nā mea nui o ka 7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9) me ka pūnaewele mana maikaʻi ma lalo o ka CGMPʻoihana
nā kauā.

Māhele:

Description

7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9) video

Product Name 7-Benzyloxy-4-chloro-6-methoxyquinazoline
IUPACName 4-chloro-6-methoxy-7-phenylmethoxyquinazoline
'O Synonyms 1. 162364-72-9
364B729
4CH-012812
4-chloro-6- (methyloxy) -7 - [(phenylmethyl) oxy] quinazoline
2. 4-chloro-6-methoxy-7- (phenylmethoxy) quinazoline
4-chloro-6-methoxy-7- (phenylmethoxy) -Quinazoline
3. 4-Chloro-6-methoxy-7-benzyloxyquinazoline
4-chloro-6-methoxy-7-phenylmethoxyquinazoline
4. 4-chloro-7-benzyloxy -6-methoxyquinazoline
5. 7- (benzyloxy) -4-chloro-6-methoxyquinazoline
7-benzyloxy4-chloro-6-methoxyquinazoline
7-benzyloxy-4chloro-6-methoxyquinazoline
7-benzyloxy-4-chloro6-methoxyquinazoline
7-benzyloxy-4-chloro-6methoxyquinazoline
6. 7-Benzyloxy-4-chloro-6-methoxyquinazoline
7. 7-BENZYLOXY-4-CHLORO-6-METHOXY-QUINAZOLINE
A23000
AB0044107
AC-22776
ACN-036693
AJ-37957
AK-25065
AKOS005255349
AM807898
AN-2283
ANW-50637
AS-18141
AX8027687
B-2144
BCP14424
BR-25065
CJ-08962
ʻO CS-B0926
CTK4D1206
DTXSID50443221
EN000147
FT-0648419
HP21522
I06-1382
KB-199862
KB-72337
LBGIYCBNJBHZSZ-UHFFFAOYSA-N
MolPort-006-389-900
OR17604
PB14384
Hana-1060
QUINAZOLINE, 4-CHLORO-6-METHOXY
7- (PHENYLMETHOXY) -
Qumazoline, 4-chloro-6-methoxy-7- (phenylmethoxy) -
SBB066214
SC-53239
ʻO SCHEMBL297514
ST2419013
TC-067611
W3540
ZINC2527305
ZX-AT015432
ʻAna 98%
Kupa CC = NC = 2 (C1 = CC (OC) = C (C = 2) OCC3 (= CC = CC = C3)))
Ka Lā Molecular C16H13ClN2O2
Kaomi Inchi LBGYCBNJBHZSZ-UHFFFAOYSA-N
Inchi 1S/C16H13ClN2O2/c1-20-14-7-12-13(18-10-19-16(12)17)8-15(14)21-9-11-5-3-2-4-6-11/h2-8,10H,9H2,1H3
Kāleka CAS 162364-72-9
CAS Min 95.0%
CAS Max 100.0%
Point Hoʻolālā 132 ° C
Molecular Weight 300.74 g / mole.
Loaʻa i ke kani pono


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2 hōʻike manaʻo no ka mea, 7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

  1. APICMO -

    Uaʻimi neiʻoe i kahi e kūʻai ai i nā mea liʻiliʻi a nui o 7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)? ʻAʻohe pono e nānā hou. Loaʻa mākou i ka pane iā APICMO. Loaʻa iā mākou ka mana e synthesi a hana i ka 7-Benzyloxy-4-chloro-6-methoxyquinazoline ma nā liʻiliʻi a me nā mea nui. Hoʻomaopopo kā mākou huahana i nā koi kānāwai o CGMP.

    7-Benzyloxy-4-chloro-6-methoxyquinazoline he huahana ma lalo o ka mahele o Quinazolines.

    7-Benzyloxy-4-chloro-6-methoxyquinazoline Hōʻike

    ʻO ka pilina ma waena e pili ana i ka mana o ka mea hoʻokūkū o phosphodiesterase10A (PDE 10A) PQ-10, me nā mea 32 e hoʻoholo ai i ka hilinaʻi o nā hoʻohui melekiki a me ko lākou mau waiwai. Ua ho'āʻo mākou i kā lākou mau hana i hiki ke hana i nā ligands o ka lolouli (PET), pehea e hiki ai iā lākou ke hana i PDE 10A a me nā PDE'ē aʻe. Hoʻomanaʻo pū mākou i ko lākou loloa i loko o ka vitro. Uaʻike nā hopena i ka hapaʻelua o ka quinazoline a alkyloxy paha i 60r 7 e pili ana i nā mea hana a me ko lākou PDE10A koho. Loaʻa ka piʻiʻana o ka koho o PDE10A na PDE3Aas ma muli o ka hoʻokomoʻana i kahi hui hana no nā molecule a iʻole quinazoline'ssixth mole mole. Ma ke paniʻana o 6, 7-difluoride ma kahi o quinoxaline, ua loaʻa iā mākou nā manaʻo like. I ka hopena, ua hōʻikeʻia keʻano palekana kiʻekiʻe loa e ka fluorinated (R) -7- (fluoromethoxy) -6-methoxy-4- (3- (quinoxalin-2-yloxy) pyrrolidine-1-yl) quinazoline (16 a), 19 ad, (R) - tert -butyl-3- (6-fluoroquinoxalin-2-yloxy) pyrrolidine-1-carboxylate (29), 35 (IC50 PDE10A 11-65 nM).

    Ma muli o ka PQ-10, ua hoʻomaikaʻi maikaʻiʻia ka hoʻokūkū'abikoki ma o ka hoʻololiʻana i ka fluoloethoxy i ka 7% o ka quinazolines. Ma ke olakino olakino, uaʻike mākou iā PDE10A e like me keʻano o ka hoʻolālāʻana i nā kumu hana āpau o ke kahawai no ka posivron. Me ke kōkuaʻana o nā hana a QSAR, ua hoʻomākaukau mākou i nā lolo fluorinateddialkoxybiarylfibers a nānāʻia iā lākou e like me nā mea hoʻopunipuni o PDE18A. Hanaʻia ka waihona 10-fluoromethoxy e like me ka mea'ē aʻe no ka hoʻomauʻana.

    7-Benzyloxy-4-chloro-6-methoxyquinazoline e loaʻa iā 11 mau ala kuhikuhi:

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    179688-01-8

    6-methoxy-7-phen ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-72-9

    4-chloro-6-ho' ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    100-39-0

    Benzyl bromide

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-72-9

    4-chloro-6-ho' ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    61032-41-5

    Methyl 4- (benzyl ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-72-9

    4-chloro6-ho' ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    3943-74-6

    methylvanilate

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-72-9

    4-chloro-6metho ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    61032-42-6

    heluhana methuyl-2-amino-4 ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-79-9

    4-chloro-6-ho' ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    205259-40-1

    Benzyl 5-kūku ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    162364-79-9

    4-chloro-6-ho' ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    121-34-6

    vanillic acid

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-79-9

    4-chloro-6-ho' ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    27883-60-9

    Methyl 4-hydroxy ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-72-9

    4-chloro-6-ho' ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    205259-41-2

    Benzyl 2-amino-5 ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-79-9

    4-chloro-6-ho' ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    91203-74-6

    Benzyl 3-kūku ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    126234-79-9

    4-chloro-6-ho' ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    56441-97-5

    Methyl 4- (benzyl ...

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    16234-79-9

    4-chloro-6-ho' ...

    Nā huahana mua

    Loaʻa ka huahana 11 hua mua. Eia nā mea penei:

    7-Benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9)

    7-Benzyloxy-4-chloro-6-methoxyquinazoline kaulike kaulike

    7-Benzyloxy-4-chloro-6-methoxyquinazoline(162364-72-9)

    7-Benzyloxy-4-chloro-6-methoxyquinazolineKākihana

    Nā kino a me nā kino kino o 7-Benzyloxy-4-chloro-6-methoxyquinazoline

    Hoʻohui

    ʻO Covalent Bond 1-kahi
    Pāleka hiki ke hoʻololiʻia 4-mau
    Waiwai Huawai ʻO nā helu helu hōʻailonaʻo 4
    ʻAʻole ka helu Donor -ʻaʻohe

    Keʻano

    7-Benzyloxy-4-chloro-6-methoxyquinazoline eʻikeʻia he keokeo'ōmaʻomaʻo

    Nā hua i heluʻia o 7-Benzyloxy-4-chloro-6-methoxyquinazoline

    Ke inoa o ka waiwai Value
    Ke kūlana kiʻekiʻe o ka Bond Bond 0
    Ke kūlana kiʻekiʻe o ka Bond Bana 0
    Ke kūlana kiʻekiʻe o ka'Āpana Atomic 0
    Ke kūlana kiʻekiʻe o ka'omomi Atom 0
    Heluhelu Atomona Heavy 21
    Kāleka Kūikawā 0
    CanonicalisedCompound oiaio
    Xlogp3-AA 3.9
    ʻIke kūpono 300.067 g / mole.
    MonoisotopicMass 300.067 g / mole.
    ʻO ke kahi'āpana o ka Mānāwai Topology 44.2 A '2
    Kālepa CACTVS Pūnaewele Pālua AAADCCB7MAAEAAAAAAAAAAAAAAAAAAAAAAA8YI
    AAAAAAAACx9AAAHGIAAAAADA6hniY31vYIFACgAyRj
    ZACCiCkxJqAJ2CA+7piNLqLF+9uGPCruwBtK6Cew0D
    'OMoIEABAgACQABAgAIEAASAAAAAAAAAAA ==
    Ka nui 325
    Molecular Weight 300.742 g / mole.

    Nā hoʻohana o 162364-79-9

    • 7-Benzyloxy-4-chloro-6-methoxyquinazoline he mea maikaʻi i ke kālaihana huahana, hoʻomohala, a me ka noiʻi.
    • He mea kūpono ia i ka uluʻana o nā maʻi.

    Nā kūlana palekana no ka lawelaweʻana i 7-Benzyloxy-4-chloro-6-methoxyquinazoline

    7-Benzyloxy-4-chloro-6-methoxyquinazolinemight i mea weliweli i kou ola inā ua hanaʻinoʻoe. No laila, e mālama ponoʻoe i ka mea hanaʻino no ka paleʻana iāʻoe iho i kekahi mau mea pili e pili ana.

    Nā Risks i pili pū me 7-Benzyloxy-4-chloro-6-methoxyquinazoline

    ʻO nā'āpana'ōpala APICMO

    ʻO kēia pūpū ka hopena o kēia pilikia:

    Hōʻike hōʻano GHS

    • ʻO ka huhū o ke kino
    • ʻO ka huhū ma nā maka
    • Hoʻopilikia i ka'ōhū hauā
    • He mea weliweli ka waiwai inā pau.

    Nā lako pilikino pilikino

    He mea nui e pale i kou kino ma ke kamaʻilioʻana me ka pūʻulu i mea e pale aku ai i kou kino i nā mea i loaʻa i luna nei. No laila, e hōʻoia iāʻoe nā lako hana pale i ka wā e hana ana me 7-Benzyloxy-4-chloro-6-methoxyquinazoline

    Ka pale pale

    E mālama i nā lole pale e uhi i kou kino holoʻokoʻa.

    E uhi i kou lima me nā pale lima pale.

    ʻO ka pale a me ka maka

    E pale i kou mau maka me nā maka palekana. Wehe pale pale maka e pale ai i kou mau maka.

    ʻO ka palekana hoʻomaha

    ʻO nā kinipona o ka'ōlohelohe e like me nā mea hoʻolālā i'āponoʻia e mākaukau no ka pilikia.

    E hōʻoia i ka lako o nā pono hana hoʻolālā hanu.

    ʻO nā mea kōkua mua

    I kekahi manawa e hana anaʻoe me 7-Benzyloxy-4-chloro-6-methoxyquinazoline, hiki i nā hanana hanana ke hiki ma kekahi manawa. Hiki i kēia mau pilikia kūlohelohe ke hōʻike i kou kino i nā pōʻino pili i ka hui. Mālama i ka kōkua mua e kōkua i ka paleʻana i nāʻino i loko o kou kino. Eia kekahi mau mea kōkua mua āu e noʻonoʻo ai i nā manawa likeʻole.

    I ke kumu o 7-Benzyloxy-4-chloro-6-methoxyquinazolineIngestion

    • Ma luna o ka hoʻohanaʻana i ka meaʻai,
    • Inu nui i ka wai ma hope o ka pauʻana. Pono ka wai a wela
    • ʻAʻole kūpono e hoʻoulu i ka luaʻi.

    7-Benzyloxy-4-chloro-6-methoxyquinazoline ka hoʻonāʻana

    Inā loaʻa ka hanu o ka hui,

    • E hoʻoneʻe i ka mea i waho i kahi'ākau.
    • E mālama i ka hoʻomaha a me ka hanuʻana o ka mea i loaʻa me ka paleʻole.
    • Eʻimi i ka'ōlelo aʻo lāʻau inā loaʻa ka huhū lōʻihi.

    Ināʻo ka pilina me ka hewa

    • E wehe i nā mea huna mai kahi pūnaewele o ka hulina.
    • E hoʻohana i ka nui o ka maʻamau, ka wai maʻemaʻe e holoi i kahi'āpana o ke kino me kaʻike.
    • Inā mau kaʻino, eʻimi i ke kōkua mai ka lāʻau lapaʻau.

    Nānā maka me 7-Benzyloxy-4-chloro-6-methoxyquinazoline

    E hoʻohana i ka nui o ka wai anuanu e holoi i nā maka no nā hola 10

    E nānā i ka leka ke loaʻa iā lākou.

    Eʻimi i ke kōkua hōʻailona ma keʻano o ka hoʻomau i ka hana.

    7-Benzyloxy-4-chloro-6-methoxyquinazoline Kaʻiʻana i nā Puʻukū

    1. Ke hoʻohanaʻia nei:

    I ka hanaʻana me 7-Benzyloxy-4-chloro-6-methoxyquinazoline, e noʻonoʻo i nā kuhikuhi ma hope nei.

    • Loaʻa i nā kuhikuhi kūpono.
    • E heluhelu i ka aʻo ma mua o ka hoʻomakaʻana e hana me ka huahana.
    • E hōʻoia i ka hawewe maikaʻi o ka wahi hana.
    • E mālama i ka lepo.
    • Mai hoʻokuʻu i ke kinona i kou pilina me kou kino a mau maka paha.
    • E hoʻohana i kahi me ka ventila maikaʻi a ma waho paha.
    • Mai hoʻolei i ke kinona i loko o nā kahawai a me nā muliwai.
    • E hōʻalo i ka hanaʻana me ka waiwai ma nā wahi i'ōwiliʻia.
    • Mai hoʻohui i nā mea hana me nā mea puhi.
    • E hōʻole i ke kāohiʻana i ke kinona i ka hana a me ka'ō'ō.
    • Mai hana i ka mea i ka wā i hāpai ai a hānai paha.
    • E hōʻole i ka puhihiwa, inu aʻai paha i ka wā e hana ana me ka lāʻau.

    Ma hope o ka hoʻohana:

    • E hoʻomaʻemaʻe i kou mau maka a me nā lima me ka wai anuanu a me ka hamo.
    • E wehe i ka lole i haumiaʻole a mai lawe i kahi mai kahi hana aiʻole e hoʻohana hou iā lākou ma mua o ka hoʻomaʻemaʻeʻana.
    • Hoʻopau keakea i nā mīkina lima e pale i ka paʻana i nā wahi i haumia.
    • E wehe i nā mīkina lima e like me ka mea i kauohaʻia e ke aupuni pekelala a kūloko paha.
    • E mālama i ke koena o ka waiwai i loko o kahi'ōmole waihona a hoʻopaʻa mau loa.
    • E wehe i ka pae hana a hoʻomaʻemaʻe.
    • E hōʻiliʻili i ka hoʻoneʻe a hoʻomohu maikaʻi i loko o nā pahu pahu hoʻopuka.

    2. Ka mālama o 7-Benzyloxy-4-chloro-6-methoxyquinazoline

    • E hoʻohana i kahi pahu momona pono'ī e mālama i ka mea hana. Hoʻopili paʻaʻo Cork i kaʻeke waihona.
    • E hōʻoia i ka hawewe kūpono o ka wahi mālama.
    • Mai noho i lalo o ka lā a me nā wahi wela. ʻAʻole pono ka mahana ma mua o 50 ° C / 122 ° F.
    • Mai wehe i ke kinowai i ka wai aiʻole nā ​​wahi maloʻo.
    • E mālama i nā keiki a me ka poʻe iʻaeʻoleʻia.

    3. ʻO ke kaʻina hana hōʻailona

    Ke keahi firefighting

    7-Benzyloxy-4-chloro-6-methoxyquinazoline a iʻole nā ​​huahanaʻelua paha e hiki ke komo i ke ahi wela. Inā hana kēia i ka hanaʻana i ka huahana, eia kekahi mau hana ahi e pono aiʻoe e noʻonoʻo:

    • E hoʻopau i ke ahi me ka lāʻau ahi e hoʻopauʻia. ʻO kēia mau mea kēia me kahi lepo maloʻo maloʻo, carbon dioxide a me ka hamo.
    • E kaua i ke ahi e komo ana i nā lole palekana. ʻO kēia ka mea e pale aku ai i ka pilina me nā maka a me kaʻili.
    • Lawe i nā mea hoʻohāhā i loko.
    • E kaua i ke ahi mai kahi mamao aku.
    • I ka nui o ke ahi a iʻole ka pāʻana, mai kaua i ke ahi. E wehe i ka pūnaewele.

    ʻO kekahi o nā puhiʻeha i loaʻa mai i ka 7-Benzyloxy-4-chloro-6-methoxyquinazoline combustion he hydrogen chloride (HCl), carbon (ii) oxyide, carbon monoxide a me hydrogen oxides (HOx).

    Nā Spillages

    I keʻano o nā pū'āihue kūlohelohe, e hōʻiliʻili i ka hoʻoneoneo a me ka hoʻokomoʻana i loko o nā pahu hoʻokuʻu inoa. E hoʻokuʻu i ka waohue e like me ke kuhikuhiʻana o nā rula hoʻoponopono'āina hoʻolālā a me ka federal.

    4. Shipping

    Ma lalo o nāʻano maʻamau,ʻaʻohe pilikia e pili ana i ka laweʻana o 7-Benzyloxy-4-chloro-6-methoxyquinazoline.

    5. Ke kūpaʻa a me ka hoʻouka

    7-Benzyloxy-4-chloro-6-methoxyquinazoline kūpaʻa ma lalo o keʻano maʻamau.

    Hoʻohuiʻia ka pūpū me nā mea ikaika a me nā mea hana hoʻoheheʻe. Eia kekahi, pale i ka hoʻomehanaʻana i ka mea hana.

    6. Nā hoʻolālā hoʻolimalima

    Hoʻopiliʻia ka hoʻoneleʻana i loko o kahi pahu kūpono kūpono a lawe i kahi hui hoʻokele laikini.

    E hahai i nā hoʻoponopono i hoʻonohoʻia e ka moku'āina a iʻole nā ​​kānāwai pekelala.

    Nāʻike kānāwai

    ʻO ke kumu mua no ka 7-Benzyloxy-4-chloro-6-methoxyquinazolineis e hoʻohanaʻia i ka noiʻi a me ka uluʻana. ʻO ka poʻe i komo i ka lawelaweʻana, pono ia, he poʻe hoʻonaʻauao i hoʻonaʻauaoʻia me kaʻike i nā hana leaka. Pono nā luna hoʻomalu i kūpono e mālama i ka hoʻohanaʻana i nā mea hana. Pono e mālama ponoʻia ka huahana me ka mahalo a mālamaʻia ma lalo o nā kūpono kūpono. ʻAʻole ka huahana no kaʻai kanaka. Manaʻo mākou he pololei kaʻike i hoʻolakoʻia ma kēia pepa i ka maikaʻi o kā mākouʻike. No laila, he mea pono e like me ke alakaʻi i hui pū me nā kumuʻike'ē aʻe.

    Kemuhana hana

    No ka hōʻoiaʻana iā mākou ke hāʻawi aku iāʻoe i ka lawelawe kūpono a me ka pono, ua hoʻokō ka pūʻulu o nā poʻe akamai i ka noiʻi a me ka hoʻomohalaʻana ma nā papahana e like me kaʻikeʻepekema, ka chromatography, kaʻike ola, ka'enekenekema i waena o nā mea'ē aʻe.

    7-Benzyloxy-4-chloro-6-methoxyquinazoline pricing a me kaʻoihana nui

    Ināʻoe eʻimi ana i kahi e hoʻonui ai i ka nui o 7-Benzyloxy-4-chloro-6-methoxyquinazoline, ua makaukau ko mākou mākaʻi aloha e hoʻolohe iāʻoe. Hiki iāʻoe ke hoʻokaʻaʻike i kā mākou lawelawe mālama kālā a hana i kāu mau kauoha nui no kāu hōʻano hou, hoʻolālā a noiʻi paha.

    Bibliography:

    1. ʻO Marcel Lindemann Sonja, HinzWinnie, Deuther-Conrad, Barbara Wenzel, Radio synthesis and in vivo evaluation of a fluorine-18 i hoʻohuiʻia he pyrazine e pili ana i ka ligandio radio no ka PET hoʻohālike o ka adenosine A 2B receptor,ʻaoʻao 2-5.
    2. Pitt, MJ I ka Handbook Handbook of Hazardous Chemicals 6thnā; Urben, PG Ed; Butterworth-Heinemann Ltd:'Oxford, 1999; Vol.2, pp301-310.
    3. Ke KōmikeʻOihana No ka'Ipele'Eolahana, US. Hale Waihona Puke Lapaʻau, Pubchem, 4,4-Difluorocyclohexanone, 1-8 Pauku.
  2. Apicmo -

    ʻO 7-Benzyloxy-4-chloro-6-methoxyquinazoline maikaʻi loa a me ka lawelawe i loaʻa iaʻu,ʻo kaʻike maikaʻi.

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