6-Iodo-3h-quinazolin-4-one (16064-08-7)

(2 Customer hōʻike manaʻo)

Ke noho nei kēia huahana ma kahi palapala pāʻani APICMO.
Loaʻa iā mākou ka mea hiki ke hana, synthesi a hana i nā mea nui o ka 6-Iodo-3h-quinazolin-4-one (16064-08-7) me ka pūnaewele maikaʻi ma lalo o nā'ōlelo hoʻolālā o CGMP.

Māhele:

Description

6-Iodo-3h-quinazolin-4-one(16064-08-7) video

ʻO 6-Iodoquinazolin-4-one, me ka helu helu CAS (16064-08-7),ʻo ia hoʻiʻo 6-Iodoquinazolin-4 (1H) -one. No kaʻano huahana o Pharmacetical. hiki ke hoʻomākaukauʻia kēia māmā e ka 2-Amino-5-iodo-benzoic acid me Essigsaeure, Formamid. Laweʻia ka hopena me ka ethanol reagent a me kahiʻano hoʻomehana no nā hola 2. ʻO nā huaʻo 87% .Ne synthesized synthesis of 3- (3-trifluoromethyllphenyl) -6-iodo-4 (3H) -quinazolinone derivatives bearing thiosemicarbazones, pyrazoles, azomethine species in C-2. Hoʻopiliʻia nā huahana i loaʻa no kā lākou hana i hanaʻia e nā mea hōʻailona'ē aʻe; ke kōpena lapaʻau o ke ola kanaka (HepG2), laina line pūpū o ka umauma (MCF-7) a me ka laina o ka laulima epithelial lung kanaka (A549). ʻO Cytotoxicity o ka pūhui synthesized i hōʻike i ka IC50 maikaʻi no kekahi mau huahana e like me ka lāʻau maʻamau, doxorubicin. I kekahiʻaoʻao,ʻo ka hanaʻauana o nā huahui synthesized against H5N1, hōʻike haʻahaʻa i ka nāwaliwali e pili ana i ka lāʻau lapaʻau Zanamivir. Uaʻike muaʻia ka 2-Aminoquinazolin-4 (3H) -ones i keʻano o nā hiʻohiʻona e alakaʻi ai i nā kaukōʻau lāʻau lapaʻau e pili ana i nā plasmepsins. Maanei, hōʻike mākou i nā haʻawina hoʻolālā alakaʻiʻana me ka pahuhopu e hoʻohaʻahaʻa i ka lipophilicity inhibitor a hoʻonui i ka kohoʻana me ka protease aspartic Cathepsin D. Ma ka hoʻomohalaʻana i kahi mahele o ka enzyme, hiki ke hoʻonohonoho i nā lālā pola (R1) i ka 5-kahi o 2-aminoquinazolin-4 (3H) -one i nā mea hoʻopaneʻeʻole e like me ka waipile carboxylic me kaʻoleʻana i ka mana enzymatic. Eia kekahi,ʻo ka hoʻokomoʻana i nā mea hoʻohui R1 ua hoʻonuiʻia nā kumu koho o nā pūnaewele i kēia moʻo pūnaewele i ka 100-fold no Plm II, IV a me CatD inhibition. ʻO ka hoʻokomoʻana o kahi pani pani pohō (R2) ma ka 7-kahoʻana o 2-aminoquinazolin-4 (3H) -one eʻae ai i ka weheʻana i kahi pū Ph mai ke kolamu THF me kaʻiliʻole i ka mana hana'āpana Plm. Ma muli o kēia mau hopena, ua hoʻolālāʻia nā mea pāpālua, e hōʻike ana i ka mana o ka Plm II a me ka IV ma keʻano haʻahaʻa a me ke koho kūʻokoʻa e pili ana iā Cathepsin D me ka lipophilicity i hoʻemiʻia a me ka hoʻonuiʻia o ka solubility.Ma ka series 3- (2,6-dimethylphenyl) quinazolinone, he huiʻano Xolino-5-yl ma kahi o ka pyrazolo [3,4-d] pyrimidine 3-kahi i alakaʻiʻia ai i kahi mea hoʻokūkū PI3Kδ (IC50 = 8.6 nM) i hoʻoukaʻia 10d, iʻoi aku ma mua o 3630, 390 a me 40 kohoʻia no PI3Kδ ma luna o PI3Ka β a me γ i ka mea i hoʻololiʻia ai me ka 3,4-dimethoxyphenyl ka mea i loaʻa i ka mea hoʻokūkū PI3Kδ / γ pono 10e a me nā helu IC50 o 8.4 nM a me 62 nM me PI3Kδ a me PI3Kγ. Uaʻoi aku ka nui o ka 10e ma mua o 1400-helu, 820-koho i koho no PI3Kδ ma luna o PI3Kα a me PI3Kβ. Ma muli o kā lākou hana pāhakiha PI3Kδʻano kupanaha, ua hōʻike nā pūnaewele 10d a me 10e i ka hana hana kū'ē kū'ē i nā pūnaewele SU-DHL-6 kanaka B. Eia kekahi, o ka mea hoʻouka helu lua o ka PI3Kδ / a me ka 10e i loaʻa nā kūpona pharmacokinetic kūpono me ka loaʻaʻana o ka plasma maikaʻi, kaʻaeʻole, ka liʻiliʻi liʻiliʻi, a me ka hoʻonaʻauao kūpono o ka 34.9percent.

6-Iodo-3h-quinazolin-4-one(16064-08-7) Specifications

CAS 16064-08-7
Ke kaʻina CAS% 95.0
Kālena CAS Max% 100.0
MDL Number ʻO MFCD00460007
InChI Key PUGXMZKDRVGIHC-UHFFFAOYSA-N
Ka inoa inoa inoa 6-Iodo-3h-quinazolin-4-hoʻokahi
Pāʻani infrared pono
ʻO ke Kino Pale Paʻa
'ōpala ʻO ka'ōmole Glass
Ka Lā Molecular C8H5IN2O
Molecular Weight (g / mol) 272.04
SMILES C1 = CC2 = C (C = C1I) C (= O) N = CN2
kala like 'ole ʻO ka Pale Yellow Red-Greyish Red
Point Hoʻolālā 271 ° C (puke.)
ʻAna ≥97.0%

6-Iodo-3h-quinazolin-4-one (16064-08-7) Ka palekana a me ka lawelawe lima

(16064-08-7) Ka wehewehe hemahema:

◆ H315-H319-H335

◆ Hanaʻia kaʻili o kaʻili.

◆ Hana i nā maka o ka maka.

◆ Hana paha i ka huhū o ka hanu.

(16064-08-7) Ka'ōlelo hoʻolaha:

◆P261-P280-P305+P351+P338-P304+P340-P405-P501a
◆ E hōʻalo i ka hoʻomahaʻana i ka lepo / fume / gas / mist / vapors / spray.
◆ Nā pale pale pale / pale pale / pale maka / maka pale.
◆ MA KA IE: E holoi mālie me ka wai no nā minuke. Wehe i nā leka hulina, inā he mau a hiki ke maʻalahi. E hoʻomau i ka holoi.
◆ KE INHALED: E hoʻokuʻu i ka ea ea e hoʻomaha i ka wahi kūpono no ka hanuʻana.
◆ E kūʻai i ka loka.
◆ Hoʻokaʻawale i nā mea / pahu me nā kūlana o ka moku / ka 'āina / aupuni / ka honua.

'Ōlelo Aʻo: Ua hoʻokumuʻia kaʻike i hoʻolakoʻia ma kēia pūnaewele e like me nā kānāwai o ka Europa (EU) a ua kūpono i ka maikaʻi o ko mākouʻike, kaʻike a me ka manaʻo i ka lā o kona hoʻolahaʻana. ʻO kaʻike i hāʻawiʻia i kūkuluʻia wale nōʻo ia ke alakaʻi no ka mālama pono a hoʻohanaʻana. ʻAʻole pono e noʻonoʻoʻia e like me ke kikowaena a iʻole ke kiko kiko'ī.

6-Iodo-3h-quinazolin-4-one(16064-08-7) Articles

Nā kiʻi hou o ka 4 (3H) -quinazolinone: nā hōʻailona a me ka loiloiʻana i nā hana antitumor a me nā antiviral.

ʻO nā huahana hou o 3- (3-trifluoromethyllphenyl) -6-iodo-4 (3H) -quinazolinone huahana e halihali ana i nā thiosemicarbazones, pyrazoles,'āmomo azomethine i C-2 i synthesi ...

ʻOihana Huakiko Lapaʻau 2018 vol. 27 # 2 p. 571 - 582,

Ka weheweheʻana o nā hua'ōlelo quinazolinone waiwai e like me nā mea hōʻoki PI3Kδ a me PI3Kδ / G

PI3Kδ a me PI3Kγ e hoʻoponopono i ka hōʻailona kamepiula. Hiki i nā mea hoʻoponopono PI3Kδ a iʻole PI3Kγ a me nā mea pāpālua o PI3Kδ / γ ka mana no ka hoʻomaluʻana i nā maʻi a me nā hematological malumancies ...

ʻO ka European Journal of Medicinal Chemistry 2018 vol. 151 p. 9 - 17,

6-Iodo-3h-quinazolin-4-one(16064-08-7) Technical Service:

Loaʻa kaʻike o kā mākou pūʻuluʻepekema ma nā wahi noiʻi a pau e pili ana i Life Science, Material Science, Synthesis Chemical, Chromatography, Analytical a me nā mea'ē aʻe.

6-Iodo-3h-quinazolin-4-one (16064-08-7) Kūpikipi Paipai & Pricing:

Loaʻa i nā mea nui no kāu kūkuluʻana, hana hana a noiʻi noiʻi paha?


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2 hōʻike manaʻo no ka mea, 6-Iodo-3h-quinazolin-4-one (16064-08-7)

  1. APICMO -

    Hiki paha iāʻoe keʻimi i kahi pilikino mele inoa nui aʻaʻoleʻoe i loaʻa i hoʻokahi? ʻO APICMO ka pane i kāu pilikia. Uaʻikeʻia mākou no ko mākou hanohano i keʻano mele mele a me nā meaʻoihana kūʻai, a ua hiki iāʻoe ke hilinaʻi iā mākou no ka hopena maikaʻi a kūpaʻa. ʻO 6-Iodo-3h-quinazolin-4-one (16064-08-7) kekahi o kā mākou mau koina i hoʻopaʻaʻia, i hanaʻia e kūpono i nā kānāwai a me nā loiloi CGMP a me ka pūnaewele maikaʻi.

    6-Iodo-3h-quinazolin-4-one (16064-08-7) description

    Aia kēia huahana i nāʻano kūʻai huahana Pharmaceutics. No ka hoʻomākaukauʻana, ua hanaʻia ma o ka inoa o 2-Amino-5-iodo-benzoic acid a me Essigsaeure Formamid. Hanaʻia ka hopena ma ke kōkuaʻana o ka ethanol a hoʻomahaʻia ia no nā hola 2. Hāʻawi ka hana i ka 87% o 6-Iodo-3h-quinazolin-4-one (16064-08-7). Eia kekahi, o ka hana e komo i ka inoa o nāʻano azomethine a me nā pyrazles thiosemicarbazoned i c-2. Ma hope o ka hoʻohālikelike, ua hoʻoponoponoʻia ka huahana i ka nānāʻana i nā hopena o ka hopena o ka'āpana anticancer ma ka pūpū o ka maʻi umauma, ka pūpū pūpū o ka ate ate o ke kanaka, nā laina lola tumora a me ka laina adenocarcinoma epithell puluma kanaka.

    Ke hoʻohanaʻia kēia huahana e like me ke kauka lāʻau waena

    Ke noho nei kēia mehana ma kaʻaelike APICMO, a no laila, e noʻonoʻoʻoleʻoe e kauoha ae noi aku iā mākou.

    ʻO ka'ōmole o ka 6-Iodo-3h-quinazolin-4-one (16064-08-7)

    6-Iodo-3h-quinazolin-4-one(16064-08-7) - APICMO

    6-Iodo-3h-quinazolin-4-hoʻokahi (16064-08-7) mea kiko'ī kiko'ī

    ʻO CAS NO. 16064-08-7
    Inoa inoa inoa 6-Iodo-3h-quinazolin-4-hoʻokahi
    Ke kuhi (g / cm 3 2.11 g / cm3
    Inoa IUPAC 6-iodo-1H-quinazolin-4-hoʻokahi
    Pākuhi 196.3 ºC
    Ka pae paila (˚C) 401 ºC ma 760 mmHg
    ʻO ke kaumaha kaulike (g / mol) 272.04
    ʻO ke kumu hāmeʻe C8H5IN2O
    Ka monoisotopic mass

    (g / mol)

    271.945 g / mole
    ʻO ke kino Pale Paʻa
    Purity 98%
    'O Synonyms 6-Iodo-3H-quinazolin-4-hoʻokahi

    4-Hydroxy-6-iodoquinazoline

    6-iodoquinazolin-4-ol

    6-iodoquinazolin-4 (3h) -one

    6-Iodo-3h-quinazolin-4-hoʻokahi (16064-08-7) mea hoʻolālā kino

    Hoʻololiʻia ka kinetona i ka wai.

    16064-08-7 ka hawewe hydrogen

    ʻO ka helu helu kūikawā 0
    Ka Waihona Waiwai Bond 1
    Waiwai Hoʻolaha HoʻolahaʻOihana 1

    6-Iodo-3h-quinazolin-4-hoʻokahi hiʻohiʻona

    ʻO kēia paʻapaʻa he paʻakikī keʻokeʻo

    6-Iodo-3h-quinazolin-4-hoʻokahi mau mea i heluʻia

    Ka Heluhelu Pāʻokoʻa Pākahi 1
    Hoʻomākaukauʻo Isotope Atom 0
    Ka Heluhelu Hoʻohālike Bond Bond 0
    Ka helu helu hōʻemiʻole 0
    Hoʻomākaukau'Āina Atom 0
    ʻO ka heluʻo Atom Stereocenter 0
    Heluhelu Atomona Heavy 12
    Kāleka Kūikawā 0
    Hoʻohanaʻia ke Kōmike oiaio
    XLogP3 1.4
    Wahi Aʻe Pola 41.5 A '2
    Ka nui 229
    Ka nui kiko 271.945 g / mole

    6-Iodo-3h-quinazolin-4-hoʻokahi ala kuhikuhi

    ʻO kēia maʻakumu he mauʻano huliʻewalu penei:

    6-Iodo-3h-quinazolin-4-one(16064-08-7)

    6-Iodo-3h-quinazolin-4-one(16064-08-7)

    6-Iodo-3h-quinazolin-4-hoʻokahi mua a me ka huahana i lalo

    Hoʻopuka

    6-Iodo-3h-quinazolin-4-one(16064-08-7)

    Product

    6-Iodo-3h-quinazolin-4-one(16064-08-7)

    6-Iodo-3h-quinazolin-4-hoʻohana kekahi

    ʻO ka huahana nui ke kumu no ka mea pili pono

    Nā pōʻino e pili ana me 6-Iodo-3h-quinazolin-4-one

    Nā hōʻailona hoʻohālikelike GHS

    ʻO nā'āpana'ōpala APICMO

    Hiki i ke kopa ke hopena i kekahi mau pilikia inā pili pololei ia i kou kino e komo pū ana;

    • Kaʻili kino a me nā meaʻaeʻae hiki ai ke alakaʻi i ka maʻi nui, kaʻulaʻula, a me ka mumū
    • ʻO ka huhū maka i hiki ke lilo i pilikia mau loa ināʻaʻole nānāʻia
    • ʻO keʻano o ka hanuʻana ke kuhū
    • I ka hopena o kaʻaiʻana, hiki i ka hopena a me ka maʻiʻana

    6-Iodo-3h-quinazolin-4-hoʻokahi kau palekana a pilikino pilikino

    E hoʻomanaʻo mau loa i kou pale lole e pale aku ai iāʻoe mai ka hele pololeiʻana me ka huahana. ʻO kēia me ka hoʻokomoʻana i nā mīkina lima kaumaha, nā maka-maka palekana, a me ka uhi maka maka me ka'elee eaʻole e hoʻopoina i ka wāwae palekana.

    1. 6-Iodo-3h-quinazolin-4-hoʻokahi (16064-08-7) mana hoʻolālā pūnaewele

    Pono e hoʻolako ponoʻia kāu wahi hana i nā lako palekana e hoʻomaopopo ai ua mākaukau maikaʻiʻoe i ka hopena o nā pōʻino pilikia a me nā mea i manaʻoʻoleʻia. Ponoʻoe e loaʻa nā mea hana e like me nā mea puhi ahi, nā mea hoʻomaʻemaʻe o ka ea, nā mea pā, a me ka hale kaʻa. E hōʻoia i ka haukaweʻana o ka hoʻolālā maikaʻi, nāʻupena me ka wai e holo ana a me kahi ua palekana.

    2. ʻO nā mea kōkua mua

    He aha kāu e hana ai inā e komo kokeʻoe i kahi pilina me ke kino? E hōʻoia e hana i kēia mau hana.

    Ka hulina pilikino

    Holo koke i ka pāpale a holoi i ka wahi i hoʻopiliʻia me ka nui o ka wai a me ka holoi holoiʻole. Inā nui kaʻona, e wehe i nā kapaʻinoʻino a holoi i ka wai ma mua o ke kauʻana i nā kapa maʻemaʻe.

    Nānā maka

    E holoi i kou mau maka me ka nui o ka wai e holo ai no nā hola 15. E mālama ponoʻole iāʻoe i nā leka ma kahi no ka hoʻomaʻemaʻe maʻalahi. Inā mau ka huhū, e noi i ke kōkua.

    Inā loaʻa ka maʻi

    Pono e hoʻokuʻuʻia ka mea i pepehiʻia i kahi ākea āpau paha i kahi manawa e loaʻa ai ka ea hou. Inā loaʻaʻo ia i nā pilikiaʻeha, hoʻoponopono i ka respiratorʻoihana ma mua o ka lawe iā ia i kahi kauka.

    ʻAina

    Pono ka wīwī e holoi i kona waha i ka wai maʻemaʻe ma mua o ka lawe 'ana i hoʻokahi hapalua o ka wai. Eʻikeʻoeʻaʻole ponoʻoe e lawe i ka luaʻi.

    3. 6-Iodo-3h-quinazolin-4-one (16064-08-7) storage

    16064-08-7 he mea hoʻonāukiuki a hiki ke'āloli koke inā mālamaʻia ma kahi o nā mea ikaika a me nā mea hana hoʻoheheʻe. E mālama iā ia mai nāʻokoʻa e hiki ke ho'āla i ia mau kuhi. Eia kekahi, e hōʻoia i ka paʻa o ka pahu. E mālama iā ia ma kahi mahana ma kahi maloʻo a ma waho o kahi hikiʻole o nā mea hanaʻole.

    4. 6-Iodo-3h-quinazolin-4-one (16064-08-7) handling

    I ka hanaʻana me kēia kinikū, e mālama pono i kēia mau mea;

    • E kau i nā pale pale e pale i ke kinakika mai ka liloʻana i kou mau maka, kaʻili, ka waha, aiʻole ka hoʻokomoʻana
    • Mai hoʻopau i kāna puhi, ka mahu a me ka lepo
    • Mai hoʻohana i kahi me nā huahana e hiki ke hoʻokuʻu i ka hoʻohahui
    • E hana mai kahi hoʻolālā maikaʻi
    • E hōʻoia i ka lako o nā mea palekana e like me nā pā, nā mea puhi ahi, a me kahi ua palekana

    5. Ma hope o ka hoʻohanaʻana i ka 6-Iodo-3h-quinazolin-4-one (16064-08-7)

    He aha kāu mau mea e hana ai ma hope o ka hanaʻana me 16064-08-7?

    • ʻO ka mea mua aʻo ka mea nui loa,ʻo ia ke mālama i kou olakala. Mai komo i nā hana'ē aʻe ma mua o ka holoiʻana i kou mau lima, e holoi a kau i nā kapa maʻemaʻe.
    • E hoʻolei aku i nā pahu a me nā koena o nā mea i hoʻokuʻuʻia a hōʻoiaʻiʻo e hoʻolei aku iā lākou ma muli o nā rula a me nā kaulike o kou moku'āina
    • E mālama pono i ke koena i kahi mahana

    6. 6-Iodo-3h-quinazolin-4-hoʻokahi (16064-08-7) nā meaʻeha

    I kekahi manawa, hikiʻole iāʻoe ke pōmaikaʻi, a hikiʻoe i kahi hanana i manaʻoʻoleʻia. ʻO kēia ka mea e hana ai i ia mau hihia;

    Pā'ā

    Ponoʻoe e hoʻomaka ma ka hamoʻana i ka mea i hoʻomohuʻia me kahi mea hoʻomehana a hoʻokuʻuʻia i loko o kahi pahu wai. E hōʻoiaʻiʻo e hoʻonāpoho i ka wahi a hoʻohana i ka puʻupuʻu puhi e kāpae i ka puhi ahi. E hōʻoia i kāu hanaʻana i kēia, ua loaʻaʻoe i nā pale pale e komo pū me kahi pale maka eʻaeʻole ai i ka hoʻomoʻana i ka mahu. E hoʻomaʻemaʻe i ka'āpana i hoʻopiliʻia me ka nui o ka wai a hoʻomaloʻo.

    ke ahi

    Hiki iāʻoe ke hoʻohana i nā huahana paleʻole e like me CO2 e hoʻopau i ke ahi.

    7. 6-Iodo-3h-quinazolin-4-one (16064-08-7) stability

    He mea paʻa kēia paʻapaʻa i ka lawelawe ponoʻiaʻana. Hoʻohana kēia i ka hoʻohanaʻana mai kahi huahana e hiki ai ke hoʻonāʻia a mālamaʻia ma ka'ākau a me ka mahana.

    8. 6-Iodo-3h-quinazolin-4-hoʻokahi (16064-08-7) hoʻokuʻu hoʻolālā

    Ponoʻoe e mālama i kēia mehana e like me ka hoʻokuʻu kūikawā a hoʻolei aku iā ia ma muli o nā lula a me nā loina o ka moku'āina, federal a me nā aupuni. Hiki iāʻoe ke kūʻai aku i ka puhiʻana i ke ahi me ka hoʻohanaʻana i kahi mea puhi ahi.

    9. 6-Iodo-3h-quinazolin-4-hoʻokahi (16064-08-7)ʻikeʻike kūʻai

    Ma keʻano he hua paʻa,ʻo 6-Iodo-3h-quinazolin-4-one (16064-08-7) hiki ke halihali maikaʻiʻia i ka nui ma ka moku a me ka ea.

    16064-08-7 hōʻike kānāwai

    Ponoʻoe e mālama i nā loina a me nā aupuni āpau, nā aupuni a me nā kānāwai āpau i nā manawa a pau o ka hanaʻana me kēia mehana.

    16064-08-7ʻikeʻikeʻike

    ʻO nāʻike a pau i hāʻawiʻia maʻaneʻi e kūpono ana ma luna o kā mākouʻike. Pono ia e alakaʻi i ka wā e hoʻohana ai i ke kinakuma a no laila,ʻaʻole mākou e pili i kāu hana. Hoʻomaʻamaʻa maikaʻiʻia kā mākou mauʻoihana a loaʻa kaʻike nui ma nā mea e pili ana i ka noʻonoʻo huahana, nā kānana kilokilo, kaʻike ola, kaʻike haʻawina, a me ka chromatography.

    6-Iodo-3h-quinazolin-4-hoʻokahi (16064-08-7) ka hoʻonohonoho pono a me ka ukuʻana.

    16064-08-7 no ka hanaʻana, ka hana, a me ka noiʻiʻana. Inā makemakeʻoe no kekahi o kēia mau kumuhana, eʻoluʻoluʻoe e hana i nā kauoha nui mai iā mākou i kēlā me kēia manawa.

    ʻia ....................

    1. Ke KōmikeʻOihana No ka'Ipele'Eolahana, US. Hale Waihona Puke Lapaʻau, PubChem 6-Iodo-3h-quinazolin-4-one (16064-08-7) Mahele 1-10.
    2. ʻO ka hoʻonohonoho'Āpana Hoʻolālā o United States, Part 4, pg 74.
    3. Friedrich Konrad Beilstein, Reiner Luckenbach, Springer-Verlag, Beilstein Manuel Handiculation of Organic Chemistry:ʻElima papahana kākoʻo i nā puke mai 1960 ma o 1979, Volume 27, Māhele 18.
    4. Kaʻaha kūkā o ka noiʻiʻike'enekema a me kaʻenehana, 2006, Nānā'Iniani o ke Kelekema: Organic me nā lāʻau lapaʻau. Māhele B Hōmelika, Organic.

  2. Apicmo -

    ʻO ka 6-Iodo-3h-quinazolin-4 maikaʻi loa a me ka lawelawe i loaʻa iaʻu,ʻo kaʻike maikaʻi.

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