Blog

2019 CNS Nānā Huakaʻi Ola Loa Monosialotetrahexosylganglioside Sodium (GM1) Pig Brain (37758-47-7)

2019 CNS Nānā Huakaʻi Ola Loa Monosialotetrahexosylganglioside Sodium (GM1) Pig Brain (37758-47-7)

Ka wehewehe Meta

Eʻike i keʻano o GM1 ma ka physiology neurological, kona mau meaʻelemakule, a me nā hopena o ke kino ma nā pūnaewele o waena a me ke kikowaena.

He aha ka Monosialotrahexosylganglioside Solidum (GM1)

ʻO Monosialotetrahexosylganglioside ka sodium he meaʻaiʻoihana neurotropic nona ka hoʻopiʻi. GM1.

ʻO Gangliosides kekahi o ka papa o ka moʻo ganglio,ʻo ia hoʻi he glycosphingolipid me ka koena o ka waipaʻa sialic ma ke kaula kō. ʻO ka'āpana polysaccharide mālili e pili ana me ka ceramide ma o ka pilina β-glycosidic. ʻAʻole wale lākou i hoʻokumuʻia i loko o ka membrane plasmic neuronal akā i loko o ka retopulum endoplasmic.

ʻOiai ua hana lākou no ka 0.1% o ka nui o ka kaumaha o ka lolo, loaʻa nā helu gangliosides no kahi 10% o ka lipids āpau. Lawe lākou i kaʻokoʻaʻana o ka cell, apoptosis, neuroprotection, a me ka hoʻokuʻuʻiaʻana o nā neurotropins.

ʻO Monosialotetrahexosylganglioside kahi hui kūponoʻole me ka'āpana oligosaccharide a me ka ceramide. ʻO ka mole e hōʻike i nā mea hydrophilic and lipophilic. Ma ka hoʻonaniʻiaʻana i ka wai a me ka momona, hiki i ka Monosialotetrahexosylganglioside ke loiloi ma o ka paleʻana i ka lolo.

ʻO Monosialotetrahexosylganglioside ka sodium GM1 kahiʻoihana physiological koʻikoʻi ma ka lolo. Hōʻikeʻia nā mea neuroprotective e like me ka hoʻoponoponoʻana i nā poho kinoʻole, ka ho'ōla hana, a me ka hoʻomou houʻana o nā neurons ma hope o kaʻeha. No kēia kumu, he mea pono ka monosialotetrahexosylgangliother sodium i ka mālamaʻana i kahiʻehaʻeha. ʻO kekahi o nā maʻi i pili i loko o kēia maʻi,ʻo ia ka maʻi trabrochinal, cerebrovascular damage, a me kaʻehaʻeha o ke kino. Hoʻonuiʻia ka nui o ia mea ma kahi o kahi hanaʻeha o ke kino.

Ka moʻaukala o Monosialotetrahexosylganglioside Sium (GM1)

Ke aʻoʻiaʻana o GM1 a me kona kuleana i loko neuroprotection nā lā i ka 1970s. Mai ia manawa, ua hōʻike ka poʻeʻepekema noiʻi i ka hoihoi ma ka pūnaewele ma o ka hoʻokomoʻana i nā moʻomeheu a me nā haʻawina holoholona. Ua nānā nā hoʻokolohua a pau i ka hoʻokumuʻana i keʻano o GM1 i nā maʻi neurodegenerative.

Ma 1986, ma o TRB SA, hoʻokuʻuʻia ka monosialotetrahexosylgangliother sodium i lalo o ka inoa kūʻai, GM-1. Ma muli o ka hoʻolahaʻana o nā hualoaʻa no nā haʻawina holoholona, ​​ua hele nā ​​kāmikūʻAmelika e nānā i nā hopena o ka Monosialotetrahexosylganglioside sodium (GM1) ma ke kanaka. ʻO nā haumāna o ka hoʻonaʻauaoʻana he mau maʻi me ka CNS hewa no ka hōʻehaʻana o ka'ōpū, ka hahau, ka maʻi o Parkinson, a Alzheimer.

Mai ia manawa, ua'āpono nā moku'āina e like me Argentina a me Italia i kāna noi lāʻau hōʻailona no ka mālamaʻana i nā maʻi neurological.

ʻO Monosialotetrahexosylganglioside Sodium(GM1)Hōʻuluʻulu Kūkulu

ʻO Monosialotetrahexosylganglioside Sodium (GM1) puaʻa puaʻa (37758-47-7)

ʻO Monosialotetrahexosylganglioside Sodium(GM1) hoakaka

Kākau CAS. 37758-47-7
Product Name ʻO Monosialotetrahexosylganglioside Sodium (GM1) Pig Brain
Inoa IUPAC (2S,4S,5R,6R)-5-acetamido-2-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5R,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-6-[(E,2R,3S)-3-hydroxy-2-(icosanoylamino)icos-4-enoxyl]-2-(hydroxymethyl)oxan-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
Kōpana Drug ʻO Sphingolipids
Point Hoʻolālā 207 - 230 ° C
Ka Lā Molecular C77H139N3O31
Ka Molecular Mass 1546.841 gmol-1
Palekana · Ka wai
· Hoʻololi ikiʻia ma ka methanol / chloroform
· Hiki ke hoʻopiliʻia i ka hanano anhydrous
Keʻano ʻO kaʻeleʻeleʻeleʻele i'āpana keʻokeʻo
Purity 98%
Ka pale Kūʻai -20 ° C
Shelf Life ʻElua makahiki
pH 5.0 ke 6.5
'O Synonyms ʻO Monosialoganglioside GM1
·Ganglioside GM1

ʻO Monosialotetrahexosylganglioside Sodium(GM1) Ka hana hana

ʻO nā monosialotetrahexosyl ganglioside e hana ana ma nāʻano he nui. ʻO ka moleula he mea hōʻike ia o ka hapa nui o nā hana physiological o ka pūnaewele pūpū.

I loko o ka membrane cell o ka lolo, hana ka Monosialotetrahexosylganglioside mau pono no ka mālamaʻana i ka pale i loko o waho a me waho o kaʻiʻo. ʻAʻole wale ia e hoʻonui i ka kūpono o ka impermeability, akā,ʻo ia pū kekahi me ka pāpaʻi sodium a me ka pīkoka.

I ke kumu o kaʻehaʻeha, ʻO Monosialotetrahexosylganglioside ka sodium (GM1) e hoʻopale i ka pilina o ka poʻe. Hoʻolālā ia i ka hana o ka A2 phospholipase, hoʻonāukiu i ka līlī o ka'āpana calcium, aʻokiʻoki i ke kūkuluʻiaʻana o nā radical free.

Hoʻopiʻi ka'ōpiopio i ka hana o ka protein kinase ma nā pūnaewele, aʻo ia ke kuleana no ka apoptosis. Hōʻole a GM1 i kēia kaʻina hana ma o ka mālamaʻana i ka metabolism o nā protein i loko o ka cytoplasm a me ka nucleus.

I loko o ka mitochorinion, ua hanaʻo Monosialotetrahexosylganglioside e hoʻoponopono i ka hanaʻana o ATP a me kāna hana synthase. Hoʻoponopono ia i nā mea e pohō ai i ke kaula kaʻa kaʻa a me ka hoʻomaikaʻiʻana i ka phosphorylation. ʻO ka hopena, ua mau ke olakino'ōpū o ka lolo.

ʻO ka monosialotetrahexosylganglioside kaʻaila sodomi e hoʻoulu i ke kumu o axonal e hoʻoulu i nā mea ulu i ko lākou mau kikooho pono'ī. Hoʻoponopono kēia hana i nā aho o ke aʻa a hoʻoulu i ka ho'ōla wikiwikiʻana. I ke kumu o ke kula kiʻekiʻe, hiki paha i kaʻino dopamine neuron, e hoʻoikaika ka monosialotetrahexosylganglioside i ka hopena a hoʻonui i ke ola o kēia mau neuron.

2019 CNS Nānā Huakaʻi Ola Loa Monosialotetrahexosylganglioside Sodium (GM1) Pig Brain (37758-47-7)

Monosialotrahexosylganglioside Solidum (GM1) Nā hopena

ʻOiai nā gangliosides ka mea liʻiliʻi loa i ka lolo, ua nui loa kā lākou mau hana. He hopena maikaʻi kēia mau molekiki i ka uluʻana, ka hoʻoponopono hou, ka hoʻoponoponoʻana, a me ka paleʻana i nā kiko o ke aʻalolo.

Ua haʻaleleʻo GM1 i ka makahiki. Hoʻopiliʻia nā mea'epiopio me ka hoʻohana nuiʻana o ka lolo, ka maʻaʻole o ka māmā, nāʻehaʻeha o ke kīpē, a me nā pauʻole o kaʻike. Ma waho aʻe, i ka paʻiʻana o nā maʻiʻelemakule paʻakikī e like me ka maʻi maʻi pīpī, ka hahau, a me ke dementia.

ʻO ke kākoʻo manawa kūponoʻo GM1 e hoʻopau i ka hapanui o nā maʻiʻelemakule. ʻO kekahi o nā hualoaʻa maikaʻiʻo Monosialotetrahexosylganglioside sodium (GM1),ʻo ia ka mālamaʻana i ka maʻi o Alzheimer, ka'ō'ō, ka maʻi wīwī a me ka maʻi pīpī. Ma waho aʻe, ho'ēmi wikiwiki ka waihona i kaʻelemakule ma hoʻoponopono i ka hoʻomanaʻo.

ʻO ka hoʻohanaʻana o GM1 ma nā polokalamu hoʻonaʻauao he nui loa. Eia kekahi laʻana,ʻo kekahi mau'āinaʻEulopa a meʻAmelika e lawe nei i ka moniumlotetrahexosylgangliother kaomi sima no ka mālamaʻana i nā maʻi CNS.

Hoʻonui ka waihona i ka uluʻana o nā pūnana nerve, ka uluʻana o nā lolo o ka lolo, a me ka paleʻana i nā maʻi neuro. ʻO ka maʻi lapaʻau, ua mālamaʻia kēia maʻiʻeleʻele i nā maʻi o ka lolo, nā hōʻailona ischemic, ka hemorrhage cerebral, a me nāʻeha puʻupuʻu pūpū.

ʻO ka mea nui loa i kaʻike a me ka hoʻohanaʻana o kēia pūnaewele ma luna o nā kānaka, uaʻikeʻo iaʻaʻole i loaʻa nā hopena o Monosialotetrahexosyl ganglioside sodium (GM1).

ʻAʻole nā ​​GM1 hopena i nā manaʻo maʻalahi. Ma ka 1976, ua hoʻopaʻaʻo Cekarelli i nā gangliosides keu e hoʻoulu i ka hoʻomau a me ka hoʻoponoponoʻana o nā pūpū iʻeha. Uaʻikeʻia kēiaʻike i kahi kahua paʻa no nā haumāna e hōʻike ana i ka hoihoi i ke aʻoʻana i ka hana a GM1 ma ka pūnaewele pūpū.

Hoʻomaopopo ka nui o nā hoʻokolohua hoʻokolohua he mea pili maikaʻi ka Monosialotetrahexosylganglioside ma ka uluʻana, kaʻokoʻa, ka uluʻana, a me ka hoʻomau houʻana i nā pūnaewele neuropie. Eia kekahi, ke aʻo houʻia ka mana o GM1 ma nā neuroprotection, neuroplasticity, a me ka transmission synaptic.

I keʻano o ka trauma, lawe i ka mea nui o Monosialotetrahexosylganglioside ka sodium hana e hoʻopōʻino i ka pūnaewele namu ma nāʻano he nui. ʻAʻole e hoʻonui wale ka mole i ka hanauna dendritic o nā pūnana nerve akā ua hoʻonui i ko lākou ola ola. ʻO ka lua, he kuleana koʻikoʻi ka waihona i ka hoʻoponopono hou, ka hoʻoponoponoʻana, a me ka ho'ōla houʻana.

ʻO Monosialotrahexosyl Ganglioside Solidum (GM1) Hōʻalo i ke Kumu

I kēia manawa,ʻo Monosialotetrahexosyl ganglioside kahi CNS wale nō e mālama ai.

ʻO ka moleula he wahi kapikala, kahi i hoʻopiliʻia me ka membrane neural cell of mammals. Ma muli o kona mauʻona waiwai i loko o nā'epi o ke kino, ua hiki i nāʻepekema a me nā kāpikakiki ke unuhi a hoʻohanaʻia i ka hoʻomākaukauʻana i ka monosialotetrahexose ganglion.

Lawe mākou i ka Monosialotetrahexosyl ganglioside mai nā pūmani mammalian. ʻOiai e hiki iāʻoe ke hoʻokaʻawale i ka mole mai ka bipi aiʻole ke kao,ʻo ka'ōnaehana palekana ka unuhi puaʻa. ʻO ke kumu,ʻo ka monosialotetrahexosyl ganglioside i laweʻia mai nā bipi a me nā kao paha, e hiki ke hoʻololi i nā kāhuna'epena e like me ka maʻi a me ka maʻi āpau.

ʻO nā mea lawaiʻa no Monosialotetrahexosylganglioside ka sodium (GM1) ke kālepaʻana i ka hanaʻana, pono, a me ka waiwai. Hāʻawi mākou iāʻoe i ka GM1 māmā a maikaʻi loa mai ka'ōpū puaʻa, no ka mea,ʻaʻole e hoʻouna ke ala i nā maʻi i ke kanaka.

No nā kūpona kiʻekiʻe, hoʻohana mākou i ke kaʻina hana hoʻokuʻu chloroform-methanol-wai. Ma hope, ua hana mākou i ka hoʻokaʻawaleʻana i kaʻike maʻalahi a me ka nuiʻole. Hiki ke hoʻomaʻemaʻeʻia kēia mole mole like,ʻo ia hoʻi> 98% hala ma o HPLC.

Panina

He mea koʻikoʻi kaʻoihana o Monosialotetrahexosyl i nāʻoihana pilikino. He lāʻau lapaʻau i'āponoʻia no ka hoʻoponoponoʻana i nā maʻi neurologic a me ka mālamaʻana i kaʻeha o waena.

Inā makemakeʻoe e kūʻai i GM1 no ka hoʻohanaʻana i ka hopena maikaʻi a iʻole ke noiʻi noiʻi, ke hōʻoia nei mākou i kāu huahana kiʻekiʻe. Hoʻonui mākou ʻO Monosialotetrahexosylganglioside sodium (GM1) ka paukū ma lalo o nā kūlana o ka mana maikaʻi.

E hoʻomaopopo '

  1. Schneider, JS, Roeltgen, DP, et al. (1998). ʻO ka maʻi o Parkinson: Hana Hanaʻia me ka GM1 Ganglioside Treatment ma kahi hoʻonaʻauao i kahi kahi i kūkuluʻia.
  2. Bansal, AS, Abdul-Karim, B., Malik, RA, et al. (1994). IgM Ganglioside GM1 Nā'Aliaki i nā maʻi me ka maʻi Autoimmune a iʻole Neuropathy, a me nā Mana. Ka Palapala Noiʻi Clinical.
  3. Mocchetti, I. (2005). ʻO Exogenous Gangliosides, Neuronal Hoʻolālā a me Repair, a me nā Neurotropins.
  4. Aureli, M., Mauri, L., Ciampa, MG, Prinetti, A., Toffano, G., et al. (2016). GM1 Ganglioside: Naʻauao i hala a me nā mea i hiki mua. ʻO ka Molecular Neurobiology.
  5. ʻO Bian, L., Yang, J., a me Sun, Y. (2015). Ka hoʻouluʻana a me ka hoʻomaʻemaʻeʻana o Monosialotetrahexosylgangliosides mai ka Pig Brain ma o ka'Āpana a me ka Liquid Chromatography.